| 沈靖,徐耀初,胡旭,吴剑南,钮菊英,沈洪兵,叶本法.食管癌的遗传度、分离比估算及比较流行病学研究[J].Chinese journal of Epidemiology,1995,16(2):105-108 |
| 食管癌的遗传度、分离比估算及比较流行病学研究 |
| Evaluation of Segregation Ratio and Hereditability of Esophageal Cancer-a Comparative Epidemiologic Study in Huai' an County |
| Received:May 16, 1994 Revised:August 16, 1994 |
| DOI： |
| KeyWord: 遗传流行病学 分离比 遗传度 比较流行病学 |
| English Key Word: Genetic epidemiology Segregation ratio Hereditability Comparative epidemiology |
| FundProject:本项研究为江苏省科委自然科学基金资助项目 |
| Author Name | Affiliation | | Shen Jing | Department of Epidemiology, Nanjing Medical University, Nanjing 210029 | | Xu Yao-chu | Department of Epidemiology, Nanjing Medical University, Nanjing 210029 | | Hu Xu | 淮安市卫生防疫站 | | 吴剑南 | 淮安市卫生防疫站 | | 钮菊英 | Department of Epidemiology, Nanjing Medical University, Nanjing 210029 | | 沈洪兵 | Department of Epidemiology, Nanjing Medical University, Nanjing 210029 | | 叶本法 | Department of Epidemiology, Nanjing Medical University, Nanjing 210029 |
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| Abstract: |
| 本文通过遗传流行病学病例对照研究,对淮安407个家系(249个先证病例,158个对照),应用Li-Mantel-Gart和Falconer方法分别进行了分离比、遗传度估算及比较流行病学研究。结果显示,淮安食管癌的分离比为0.1347,明显低于0.25,属多基因遗传方式,遗传度为21.41%,女性(20.23%)明显高于男性(13.57%)。同时对肺、胃、肝、大肠等部位癌症的遗传因素作用进行了比较流行病学研究,可见各部位癌症的分离比(除胃癌未见有关报道外)均小于0.25,遗传度以胃癌和肝癌相对较高,分别为52.40%和51.85%。本研究为明确遗传因素与癌症的关系提供了有力证据。 |
| English Abstract: |
A genetic epidemiologic case-control study including 407 pedigrees (249 cases and 158 controls) was carried out to estimate the segregation ratio and the hereditability (h2) of esophageal cancer by using the method of Li-Mantel-Gart and Falconer, respectively, and to compare the genetic epidemiologic features from the other cancers.
The results showed that the segregation ratio of esophageal cancer was 0.1347, significantly less than 0.25 and the genetic model belonged to polygenetics. The h2 of esophageal cancer was 21.41%, 20.23% for female and 13.57% for male. It is concluded that genetic factor is one of the risk factors for esophageal cancer and specially of importance for female, but it is not a main risk factor for esophageal cancer. The results of comparative epidemiologic study among the cancers of lung, stomach, liver and large bowel showed that the segregation ratios of the cancers (except stomach, no data) were all less than 0.25,and the h2 of gastric and liver cancers were higher,which were 52.40% and 51.85%, respectively. |
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