尿石症危险因素人群病例对照研究

张顺祥; 李良成; 江英; 施侣元; 项普生; 黄向南

Abstract

张顺祥,李良成,江英,施侣元,项普生,黄向南.尿石症危险因素人群病例对照研究[J].Chinese journal of Epidemiology,2002,23(4):273-276

尿石症危险因素人群病例对照研究

A population-based case-control study on the risk factors of urinary calculi

Received:November 26, 2001 Revised:August 06, 2012

DOI：

KeyWord: 尿石症危险因素病例对照研究

English Key Word: Urinary calculi Risk factor Case control study

FundProject:

Author Name	Affiliation
Zhang Shunxiang	Shenzhen Sanitary and Anti epidemic Station, Shenzhen 518020, China
Li Liangcheng	Shenzhen Sanitary and Anti epidemic Station, Shenzhen 518020, China
Jiang Ying	Shenzhen Sanitary and Anti epidemic Station, Shenzhen 518020, China
Shi Luyuan	华中科技大学流行病学教研室
Xiang Pusheng	深圳市麒麟山疗养院
Huang Xiangnan	深圳市人民医院体检科

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Abstract:

目的　探索尿石症发病的危险因素 ,为人群预防提供依据。方法　选取深圳市尿石症现况调查发现的 334例患者为病例组 ,721名健康者为对照组 ,进行尿石症危险因素人群病例对照研究 ;采用非条件logistic回归对 34个变量进行分析 ,采用Falconer回归法估算遗传度。结果　尿石症病例组和对照组配比条件均衡可比 ,单因素logistic回归分析共有 17个变量有统计学意义 ,但最终进入模型的因素有 10个 ,其中 4个变量为尿石症发病危险因素 ,OR值大小依次为既往泌尿系慢性炎症史 (OR =4 .09,95 %CI :1.38～ 12 .14 )、一级亲属尿石症史 (OR =2 .61,95 %CI :1.70～ 4 .01)和多食动物蛋白质 (OR =2 .14 ,95 %CI:1.71～ 2 .69)、暴露日照时间长 (OR =1.39,95 %CI :1.16～1.66 ) ;而较高文化程度 (OR =0 .46 ,95 %CI :0 .29～ 0 .73)、日引水量多 (OR =0 .59,95 %CI :0 .48～0 .72 )、饮果汁 (OR =0 .41,95 %CI :0 .18～ 0 .94 )、多食奶及奶制品 (OR =0 .82 ,95 %CI :0 .68～0 .99)、多食蔬菜 (OR =0 .70 ,95 %CI:0 .55～ 0 .91)和多食水果 (OR =0 .78,95 %CI :0 .64～ 0 .94 ) 6个变量为尿石症发病的保护因素。一级亲属尿石症患病率病例组高于对照组 ,尿石症分离比为0 .0109,95 %CI:0 .00 50～ 0 .01。

English Abstract:

Objective To determine the risk factors of urinary calculi in Shenzhen for proper interventions. Methods A population based case control study including 334 urinary calculi cases and 721 controls was carried out. A total number of 34 factors were analyzed using unconditional logistic regression. Results Seventeen factors were associated with urolithiasis based on the logistic regression analysis. Ten factors entered the last model of the logistic multivariate regression. The more protein consumption ( OR = 2.14 , 95% CI : 1.71 2.69 ), positive history of first relatives with urolithiasis( OR = 2.61 , 95% CI : 1.70 4.01 ), longer outdoor exposure( OR = 1.39 , 95% CI : 1.16 1.66 ) and chronic inflammation of urinary system( OR = 4.09 , 95% CI : 1.38 12.14 ) were risk factors of urinary calculi. Higher education background ( OR = 0.46 , 95% CI : 0.29 0.73 ), drinking more water( OR = 0.59 , 95% CI : 0.48 0.72 ), drinking more juice( OR = 0.41 , 95% CI : 0.18 0.94 ), more milk and milk product consumption ( OR = 0.82 , 95% CI : 0.68 0.99 ), vegetable ( OR = 0.70 , 95% CI : 0.55 0.91 ) and fruit consumption ( OR = 0.78 , 95% CI : 0.64 0.94) were protective factors of urolithiasis. Conclusion Dietary habits were the major influencing factors of urinary calculi. Positive history of family with urolithiasis and social economic factors were also associated with the disease.

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