| 吴桂贤,吴兆苏,刘静,王薇,赵冬,厚磊,曾哲淳,王文化,刘军,秦兰萍,刘飒.11省市代谢综合征患者中心脑血管病发病率队列研究[J].Chinese journal of Epidemiology,2003,24(7):551-553 |
| 11省市代谢综合征患者中心脑血管病发病率队列研究 |
| A study on the incidence of cardiovascular disease on the metabolic syndrome in 11 provinces in China |
| Received:September 22, 2002 |
| DOI： |
| KeyWord: 心脑血管病 代谢综合征 发病率 |
| English Key Word: Cardiovascular diseaseo Metabolic syndromeo Incidence rate |
| FundProject:国家“八五”科技攻关资助项目(859150102) |
| Author Name | Affiliation | | Wu Guixian | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Wu Zhaosu | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Liu Jing | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Wang Wei | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Zhao Dong | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Hou Lei | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Zeng Zhechun | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Wang Wenhua | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Liu Jun | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Qin Lanping | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China | | Liu Sa | Department of Epidemiology, Beijing Heart, Lung and Blood Vessel Medical Center, Beijing 100029, China |
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| Abstract: |
| 目的 探讨队列人群代谢综合征与心脑血管病发病率的关系.方法 采用11省市队列人群(35～64岁)共27739人于1992年进行基线危险因素调查的资料,计算队列人群代谢综合征患者在观察终点心脑血管病事件的人年标化发病率,用Cox回归模型预测危险因素水平与发病率之间的相关性.结果(1)11省市队列人群代谢综合征患者心脑血管病人年标化发病率明显高于无代谢综合征者(分别为652.310万和206.710万,二者RR=3.12,P <0.001);(2)有高血压、低高密度脂蛋白和高腰围者心脑血管病人年标化发病率最高(男性910.210万,女性930.710万);(3)男性年龄、吸烟、体重指数、总胆固醇和代谢综合征是心脑血管病发病的最重要的预测因素,女性为年龄、体重指数和代谢综合征.结论11省市队列人群代谢综合征患者心脑血管病人年标化发病率明显高于无代谢综合征者,代谢综合征是心脑血管病发病的最重要的预测因素(尤其脑血管病),心脑血管病危险因素的一级和二级预防势在必行. |
| English Abstract: |
| Objective To explore the association of metabolic syndrome with CVD in a cohort study involing 11 provinces.Methods A cohort study was carried out in a population of 27739 subjects(age 35-64 years).A baseline survey on the risk factor of cardiovascular disease was done in 1992. Incidence rate and relative risk were calculated for metabolic syndromes.Results (1)The age-standar-dized incidence rate of cardiovascular disease for metabolic syndromes(MS) was higher than those without(MS) in this cohort (MS 652.3/ 100 000} not MS 206. 7/100 000} RR=3.12,P<0.001).(2)The incidence rate of cardiovascular disease for patients with hypertension but low HDL cholesterol and high waist was the highest (910.2/100 000 in man}930.7/100 000 in woman) among all metabolic syndromes patie-nts.(3) The predictive risk factors for cardiovascular disease were age,cigarette smoking BMI,total cholesterol and metabolic syndrome in men, with age,BMI and metabolic syndrome in women.Conclusion The incidence rate of cardiovascular disease on the metabolic syn-drome was high in 11 provinces in China. Age BMI and metabolic syndrome were the predictive risk factors of cardiovascular disease (es-pecially of cerebrovascular disease).It is essential to prevent risk factors of cardiovascular disease in primary and secondary preven-tion programs in general population. |
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