X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性

朱虔兮; 边建超; 沈强; 江峰; 汤洪伟; 张宏伟; 吴毅

Abstract

朱虔兮,边建超,沈强,江峰,汤洪伟,张宏伟,吴毅.X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性[J].Chinese journal of Epidemiology,2004,25(8):702-705

X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性

Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma

Received:July 03, 2003

DOI：

KeyWord: 乳头状甲状腺肿瘤 X线交错互补修复基因1 基因多态遗传易感性危险因素

English Key Word: Papillary thyroid carcinoma X-ray repair cross-complementing gene 1 Genetic polymorphism Genetic

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Author Name	Affiliation	E-mail
Zhu Qianxi	Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Bian Jianchao	Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China	jcbian@shmu.edu.cn
Shen Qiang	Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Jiang Feng	Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Tang Hongwei	复旦大学附属肿瘤医院头颈肿瘤科
Zhang Hongwei	复旦大学附属肿瘤医院头颈肿瘤科
WU Yi	复旦大学附属中山医院普外科

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Abstract:

目的探讨X线交错互补修复基因1(XRCC1)多态与乳头状甲状腺癌(PTC)的关系.方法采用以医院为基础的配对病例对照研究设计,应用聚合酶链反应-限制性片段长度多态性技术检测105对病例和对照的XRCC1基因多态.结果病例组和对照组XRCC1第194密码子的Arg/Arg、Arg/Trp和Trp/ Trp基因型频率分别为47.6%、49.5%、2.9%和45.7%、48.6%、5.7%,两组差异无显著性(Y²=1.07,P=0.59).病例组和对照组第399密码子的Arg/Arg、Arg/Gin和Gln/Gln基因型频率分别为46.7%、41.9%、11.4%和54.2%、42.9%、2.9%,两组差异有显著性(X²=6.40,P= 0.04).以Arg/Arg基因型为参照,Gln/Gln基因型者发生PTC的风险增加,OR值为4.65(95%CI:1.24～17.45).多因素条件logistic回归分析表明,第399密码子基因多态和负性生活事件与PTC存在正关联,OR值分别为2.71(95%CI:1.22～6.05)和5.34(95%CI:1.40～20.38);X线照射史与PTC存在负关联,OR值为0.38(95%CI:0.12～0.72);未发现第194密码子基因多态、饮茶、水果和经济水平与PTC存在关联.结论XRCC1第399密码子Gln/Gln基因型可能是PTC的易感基因型,负性生活事件是PTC的可能危险因素,X线照射史是PTC的可能保护因素.

English Abstract:

Objective To study the association of polymorphisms in the X-ray repair cross-complementing gene 1 (XRCC1) and papillary thyroid carcinoma (PTC).Methods A hospital based,matched case-control study was carried out. The polymorphisms in XRCC1 for 105 pairs of cases with PTC and controls were identified by PCR-RFLP.Results The frequencies of Arg/Arg,Arg/Trp and Trp/Trp genotypes at XRC-C1 Arg194Trp site were 47.6%,49.5% and 2.9% among cases compared to 45.7%,48.6% and 5.7% among controls.There was no statistically sig-nificant difference between the two groups (χ²=1.07,P=0.59).The frequencies of Arg/Arg,Arg/Gln and Gln/Gln genotypes at XRCC1 Arg399Gln site were 46.7%,41.9% and 11.4% among cases,while 54.2%,42.9% and 2.9% among controls respectively.There was stati-stically significant difference between the two groups (χ²=6.40, P=0.04).Individuals with Gln/Gln genotype had a 3.6 5-fold increased risk of developing PTC compared to Arg/Arg genotype (OR=4.65,95% CI:1.24-17.45 ).The multivariate cond-itional logistic regression analysis showed that the XRCC1 Arg399Gln polymorphism, negative life events and X-irradiation history were associated with PTC,with odds ratios of 2.71(95%CI:1.22-6.05),5.34(95%CI:1.40-20.38) and 0.38(95% CI:0.12-0.72) respectively.However,XRCC1 Arg194Trp polymorphism, drinking tea,fruit and economic levels did not show statistically significant asso-ciations with PTC.Conclusion The Gln/ Gln genotype at XRCC1 Arg399Gln site and negative life events significantly increased wh-ile X-irradiation history decreased the risk of developing PTC.

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