| 王宏伟,何静,张泮河,汤芳,王天宝,栾一禾,吕辉,曹朝阳,吴晓明,赵秋敏,刘玮,曹务春.mxA基因多态性与SARS病毒易感性的病例对照研究[J].Chinese journal of Epidemiology,2005,26(8):574-577 |
| mxA基因多态性与SARS病毒易感性的病例对照研究 |
| A case 2 control study on the mxA polymorphisms and sus cept ibi l ity to severe acute respi r atory synd romesvirus |
| Received:October 29, 2004 |
| DOI： |
| KeyWord: 严重急性呼吸综合征 mxA基因 病例对照研究 |
| English Key Word: Severe acute respiratory syndromes mxA gene Case2 controlstud |
FundProject:国家重点发展计划“863”计划资助项目(2003AA208406,2003AA208412C);
欧盟EPISARS基金资助项目(511063);
美国NIHCIPRA基金资助项目(NIHU19AI51915) |
| Author Name | Affiliation | E-mail | | WANG Hong-wei | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | HE Jing | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | ZHANG Pan-he | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | TANG Fang | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | WANG Tian-bao | 北京武警总队医院 | | | LUAN Yi-he | 北京武警总队医院 | | | LV Hui | 北京武警总队医院 | | | CAO Zhao-yang | 北京武警总队医院 | | | WU Xiao-ming | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | ZHAO Qiu-min | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | LIU Wei | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | | | CAO Wu-chun | EpidemiologicalDepartment of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China | caowc@nic.bmi.cn |
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| Abstract: |
| 目的探讨黏病毒抗性蛋白1(MxA)基因多态性与人群严重急性呼吸综合征(SARS)发病间的关系。方法采用病例对照研究,用聚合酶链反应限制性片段长度多态性分析检测mxA基因启动子88位G/T多态性位点,对SARS传播的相关因素进行问卷调查,并用SPSS软件进行单因素和多因素分析。结果选取了66例SARS病例和64名对照进行研究。与GG基因型相比,含等位基因T的基因型(GT+TT)在病例中的构成比(81.3%)显著高于对照组(62.5%),OR值(95%CI)为2.700(1.208～6.037)。多因素logistic回归分析结果表明,在调整了与SARS病例接触时戴口罩,穿防护服,戴眼罩等相关因素后,与GG基因型相比,含等位基因T的基因型(GT+TT)仍与SARS发病有显著性关联,调整OR值(95%CI)为2.911(1.027～8.250)。结论mxA基因启动子88位G/T多态性可能与中国汉族人群SARS发病的基因易感性有关。 |
| English Abstract: |
| Objective To investigate the association between the genetic polymohisms ofmyxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes(SARS).Methods A case-control study was conducted and polymerase chain reactioirrestriction fragment lengthpolymoxphism(PCR-RFLP) was used to detect the T/ G polymorphism at position-88 in the mxA genepromoter. Information on related factors of SARS was collected using a pre-testing questionnaire.Univariate and multivariate logistic analyses were conducted with SPSS software package. Results Sixtysix cases and sixtyfour controls were selected for the study. Comparing with GG genotype，the proportionof GT genotype were significantly higher in the case group (81.3%)than that in the control group (62. 5%)with an OR (95%Old of 2. 700 }l.208-6. 037).Multivariate logistic regression analysis revealed that thesignificant association remained after factors as wearing masks，protection gowns and eye-protection whencontacting with SARS patient etc. were adjusted with an OR (95%CTl} of 2.911(1.027- 8.250).Conclusion mxA promoter88C} T SNP might be confered to host genetic susceptibility to SARS inChinese Han population. |
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