呼气负压技术检测慢性阻塞性肺疾病患者呼气气流受限的可重复性分析

陈瑞; 陈炼; 陈荣昌; 陈新

Abstract

陈瑞,陈炼,陈荣昌,陈新.呼气负压技术检测慢性阻塞性肺疾病患者呼气气流受限的可重复性分析[J].Chinese journal of Epidemiology,2010,31(12):1397-1399

呼气负压技术检测慢性阻塞性肺疾病患者呼气气流受限的可重复性分析

Reproducibility of the negative expiratory pressure technique in detecting expiratory flow iimitation on chronic obstructive pulmonary disease patients

Received:August 05, 2010

DOI：1O.3760/cma.j.issn.0254—6450.2010.12.016

KeyWord: 肺疾病，慢性阻塞性呼吸困难呼气流速受限

English Key Word: Pulmonary disease,chronic obstructive Dyspnea Expiratory flow limitation

FundProject:广东省自然科学基金研究团队项日(04205342)

Author Name	Affiliation	E-mail
Chen Rui	Department of Respiratory Diseases,the Second Hospital Affiliated to SUN Yutqen University,Guangzhou 510120,China，	gzchenrui@l63.com
Chen Lian	Out Patient Department,Guangdong Provincial RenminHospital
Chen Rongchang	State Key Laboratoryfor Respiratory Diseases. Guangzhou Medical College
Chen Xin	Department of Respiratory Diseases．the Zhujiang Hospital Affiliated to Nan Fang Medical University

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Abstract:

目的分析呼气负压(NEP)技术检测慢性阻塞性肺疾病(COPD)患者呼气气流受限(EFL)的可重复性.方法不同时间分别2次采用NEP技术检测72例COPD患者EFL.采用检验分析前后2次检测3分法EFL评分、5分法EFL评分诊断EFL的一致性,采用配对t检验分析前后2次检测气流受限(FL)指数评价EFL的可重复性.结果第1次测试时,72例COPD患者中54例(75%)出现EFL,18例无EFL,18例仅卧位出现EFL,36例坐位和卧位均检测到EFL.应用3分法评分,第1次测试和第2次测试有58例检测结果前后一致,Kappa系数为0.001).应用5分法评分,第1次测试和第2次测试有52例检测结果前后一致,Kappa系数为0.001).第1次和第2次测试FL指数在坐位(P<0.05)和卧位(P结论应用NEP技术检测COPD患者EFL,3分法和5分法EFL评分的重复性较好,FL指数的重复性较差.在NEP技术临床推广应用前,还需进一步探讨其特性.

English Abstract:

0bjective To evaluate the reproducibility ofNegative Expiratory Pressure(NEP) technique in detecting expiratory flow limimtion(EFL)on chronic obstructive pulmonary disease (COPD)patients．Methods EFL Was evaluated with NEP technique in 72 subjects having stable COPD on two occasions．Agreement between testing occasions Was assessed with the K statistic for the 3-point and 5-point EFL scores，and with paired t-test for FL index．Results On the first testing occasion，l8 subjects had no EFL。1 8 subjects had EFL in the supine position，and 36 subjects in the sitting and the supine position．Using the 3-point score，agreement Was present in 58 of the 72 subjects at time 2(K=0．69，PConclusion Both 3-point and 5-point scores provided a reproducible assessment of EFL on COPD patients but the FL index seemed less reproducible．More research were needed before NEP technique Was promoted to be used clinically．

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