| 武珊珊,孙凤,詹思延.偏倚风险评估系列:(三)交叉设计随机对照试验[J].Chinese journal of Epidemiology,2017,38(10):1436-1440 |
| 偏倚风险评估系列:(三)交叉设计随机对照试验 |
| Bias risk assessment:(3) Revised Cochrane bias risk assessment tool for individual randomized, cross-over trials (RoB2.0) |
| Received:April 01, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.10.028 |
| KeyWord: 偏倚风险 评估工具 随机对照试验 交叉设计 系统综述 |
| English Key Word: Risk of bias Tool for assessment Randomized controlled trial Cross-over design Systematic review |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wu Shanshan | National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China | | | Sun Feng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Center of Evidence-Based Medicine and Clinical Research, Peking University, Beijing 100191, China | | | Zhan Siyan | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Center of Evidence-Based Medicine and Clinical Research, Peking University, Beijing 100191, China | siyan-zhan@bjmu.edu.cn |
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| Abstract: |
| 针对交叉设计随机对照试验Cochrane偏倚评估工具2.0版本（RoB2.0）的主要内容进行详细介绍，主要阐述了与平行设计RoB2.0的不同之处，并举例说明交叉设计RoB2.0的使用方法和注意事项。交叉设计RoB2.0针对交叉设计的自身特点，设置了相应的信号问题，为交叉设计试验纳入系统综述进行证据整合提供偏倚风险信息。 |
| English Abstract: |
| This paper introduces the revised Cochrane bias risk assessment tool for individual randomized, cross-over trials (RoB2.0), comparing RoB2.0 of cross-over design with RoB2.0 of parallel design, and illustrating the application of RoB2.0 for cross-over trials in a published clinical trial. As a comprehensive tool specially designed for cross-over design, it provides more information on risk of bias in systematic reviews for the evidence synthesis. |
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