哈尔滨市人群饥荒暴露对中老年期慢性病患病风险的影响

金珊珊; 于波; 闫世春; 孙巍; 崔晓明; 周雪; 杨丽秋; 那立欣; 郭彧; 卞铮; 李立明; 陈铮鸣

Abstract

金珊珊,于波,闫世春,孙巍,崔晓明,周雪,杨丽秋,那立欣,郭彧,卞铮,李立明,陈铮鸣.哈尔滨市人群饥荒暴露对中老年期慢性病患病风险的影响[J].Chinese journal of Epidemiology,2018,39(10):1314-1318

哈尔滨市人群饥荒暴露对中老年期慢性病患病风险的影响

Effect of famine exposure on the risk of chronic disease in later life among population in Harbin

Received:December 25, 2017

DOI：10.3760/cma.j.issn.0254-6450.2018.10.005

KeyWord: 饥荒暴露慢性病回顾性队列研究

English Key Word: Famine exposure Chronic disease Retrospective cohort study

FundProject:国家重点研发计划精准医学研究重点专项（2016YFC0900500，2016YFC0900501，2016YFC0900504）；中国香港Kadoorie Charitable基金；英国Wellcome Trust（202922/Z/16/Z，088158/Z/09/Z，104085/Z/14/Z）

Author Name	Affiliation	E-mail
Jin Shanshan	Harbin Medical University, Harbin 150081, China Nangang District, Harbin Center for Disease Control and Prevention, Harbin 150056, China
Yu Bo	Nangang District, Harbin Center for Disease Control and Prevention, Harbin 150056, China
Yan Shichun	Heilongjiang Center for Disease Control, Harbin 150036, China
Sun Wei	Heilongjiang Center for Disease Control, Harbin 150036, China
Cui Xiaoming	Heilongjiang Center for Disease Control, Harbin 150036, China
Zhou Xue	Heilongjiang Center for Disease Control, Harbin 150036, China	snowweek@hotmail.com
Yang Liqiu	Nangang District, Harbin Center for Disease Control and Prevention, Harbin 150056, China	ngqmanbing@163.com
Na Lixin	Harbin Medical University, Harbin 150081, China
Guo Yu	Chinese Academy of Medical Sciences, Beijing 100730, China
Bian Zheng	Chinese Academy of Medical Sciences, Beijing 100730, China
Li Liming	Peking University School of Public Health, Beijing 100191, China
Chen Zhengming	Nuffield Department of Population Health, Center for Clinical and Epidemiological Studies, University of Oxford, Oxford OX3 7LF, UK

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Abstract:

目的研究哈尔滨市人群的饥荒暴露对中老年期糖尿病、肥胖、高血压、冠心病和脑卒中等慢性病患病风险的影响。方法以中国慢性病前瞻性研究（China Kadoorie Biobank，CKB）项目哈尔滨市的基线调查人群为研究对象，采用回顾性队列研究设计，应用logistic分析比较饥荒暴露人群与非饥荒暴露人群中老年期糖尿病、肥胖、高血压、冠心病和脑卒中等慢性病患病风险的差异。结果调整影响因素后，饥荒暴露人群的肥胖（OR=1.204，95% CI：1.104~1.313，P<0.01）、高血压（OR=1.315，95% CI：1.210~1.429，P<0.01）和冠心病（OR=1.495，95% CI：1.369~1.632，P<0.01）的危险性高于非饥荒暴露人群。饥荒暴露年龄越小，中老年期各种慢性病发生风险越大。结论饥荒暴露是肥胖、高血压和冠心病的危险因素。保证生命全过程，尤其是生命早期和青少年期的营养充足对预防中老年期肥胖、高血压和冠心病具有重要意义。

English Abstract:

Objective To study the relations between famine exposure and the risk of chronic diseases as diabetes mellitus, obesity, hypertension, coronary heart disease and stroke in the population of Harbin. Methods Our data was collected from the baseline survey-the China Kadoorie Biobank project (CKB) in Harbin. Retrospective cohort study design was used. Related risks on chronic diseases including diabetes mellitus, obesity, hypertension, coronary heart disease and stroke, were compared among the famine exposed or non-exposed people, respectively by logistic analysis method. Results After adjusted for factors as age, sex, physical activity, smoking, alcohol intake, diet, family history of diseases, it appeared that the factor ‘famine exposure’ had increased the risks of diseases as obesity (OR=1.204, 95% CI:1.104-1.313, P<0.01), hypertension (OR=1.315, 95% CI:1.210-1.429, P<0.01) and coronary heart disease (OR=1.495, 95% CI:1.369-1.632, P<0.01). The lower the age of population being exposed to famine, the greater the risk of the development of all kinds of chronic diseases. Conclusions Famine exposure appeared a risk factor for obesity, hypertension, and coronary heart disease. It is of great significance to ensure the life-long nutrition of the people, especially in the early and adolescent stages, to prevent obesity, hypertension, and coronary heart disease in their later lives.

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