| 代子瑞,邵雪君,陶云珍,沈思,冯爽,任少龙,栾琳,张钧,田健美,张涛,赵根明.苏州市区2010-2014年5岁以下儿童流感嗜血杆菌相关社区获得性肺炎的住院率估计[J].Chinese journal of Epidemiology,2021,42(7):1246-1251 |
| 苏州市区2010-2014年5岁以下儿童流感嗜血杆菌相关社区获得性肺炎的住院率估计 |
| Estimation of hospitalization rate of Haemophilus influenzae associated community-acquired pneumonia in children under 5 years in Suzhou, 2010-2014 |
| Received:January 11, 2021 |
| DOI：10.3760/cma.j.cn112338-20210111-00029 |
| KeyWord: 流感嗜血杆菌 社区获得性肺炎 住院率 儿童 |
| English Key Word: Haemophilus influenzae Community-acquired pneumonia Hospitalization rate Children |
| FundProject:上海市公共卫生体系建设三年行动计划（2020-2022）重点学科（GWV-10.1-XK16）；中美新发和再发传染病合作项目（5U2GGH000018） |
| Author Name | Affiliation | E-mail | | Dai Zirui | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Shao Xuejun | Department of Infection, Children's Hospital of Soochow University, Suzhou 215003, China | | | Tao Yunzhen | Department of Infection, Children's Hospital of Soochow University, Suzhou 215003, China | | | Shen Si | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Feng Shuang | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Ren Shaolong | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Luan Lin | Department of Infectious Disease Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China | | | Zhang Jun | Department of Infectious Disease Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China | | | Tian Jianmei | Department of Infection, Children's Hospital of Soochow University, Suzhou 215003, China | | | Zhang Tao | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Zhao Genming | Department of Epidemiology, School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | gmzhao@shmu.edu.cn |
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| Abstract: |
| 目的 估计苏州市区<5岁儿童流感嗜血杆菌相关社区获得性肺炎的住院率。方法 回顾性收集2010-2014年因社区获得性肺炎在苏州大学附属儿童医院住院治疗的<5岁儿童的病历资料及细菌学检测结果，描述流感嗜血杆菌的检出情况，并通过苏州市CDC免疫接种平台获取市区儿童人口数，估计流感嗜血杆菌相关社区获得性肺炎的住院率。结果 2010-2014年共纳入28 043例社区获得性肺炎住院病例，19 526例（69.63%）进行了细菌学检测，流感嗜血杆菌总阳性率为11.06%（2 160/19 526），其中12~23月龄组阳性率最高（14.29%，550/3 850），冬、春季高于夏、秋季（χ2=455.11，P<0.01）；<5岁儿童流感嗜血杆菌相关社区获得性肺炎的年均住院率为760.36/10万（95%CI：733.70/10万~787.01/10万），冬、春季（898.79/10万、1 249.52/10万）高于夏、秋季（514.35/10万、359.04/10万），男性（942.12/10万）高于女性（563.76/10万），差异均有统计学意义（P<0.01），1~5月龄组年均住院率最高（2 478.31/10万），随年龄增长住院率逐渐下降（χ2=2 129.80，P<0.01）。结论 苏州市区<5岁儿童流感嗜血杆菌相关社区获得性肺炎住院率较高，<6月龄组住院率最高。 |
| English Abstract: |
| Objective To estimate the hospitalization rate of Haemophilus (H.) influenzae associated community-acquired pneumonia in children under 5 years in Suzhou. Methods From 2010 to 2014, medical records and bacteriology results of children under 5 years hospitalized with community-acquired pneumonia in Children's Hospital of Soochow University were collected, retrospectively. Detection rate of H. influenzae was describe. The hospitalization rate of H. influenzae associated community-acquired pneumonia was estimated using the number of local children in urban area of Suzhou, which was obtained from the immunization platform of Suzhou Center for Disease Prevention and Control.Results A total of 28 043 hospitalized pneumonia cases were included from 2010 to 2014, in which 19 526 (69.63%) had bacteriological examination. The overall detection rate of H. influenzae was 11.06% (2 160/19 526), and children aged 12-23 months had the highest positive rate (14.29%, 550/3 850), and the rate was higher during winter-spring than during summer-autumn (χ2=455.11,P<0.01). The average hospitalization rate of H. influenzae associated pneumonia in children under 5 years was 760.36/100 000 (95%CI:733.70/100 000-787.01/100 000), which was higher in winter and spring (898.79/100 000 and 1 249.52/100 000) than in summer and autumn (514.35/100 000 and 359.04/100 000), and the hospitalization rate was higher in boys (942.12/100 000) than in girls (563.76/100 000), the differences were all significant (P<0.01). The highest hospitalization rate was observed in children aged 1-5 months (2 478.31/100 000) and the hospitalization rate decreased with age (χ2=2 129.80, P<0.01).Conclusion There was a considerable burden of H. influenzae associated community-acquired pneumonia in children under 5 years in Suzhou, especially in children under 6 months. |
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