| 史可香,朱蕴卿,余灿清,吕筠,郭彧,裴培,杨玲,杜怀东,陈怡平,陈君石,陈铮鸣,李立明,代表中国慢性病前瞻性研究项目协作组.中国成年人慢性阻塞性肺疾病与骨密度的相关性分析[J].Chinese journal of Epidemiology,2023,44(2):221-228 |
| 中国成年人慢性阻塞性肺疾病与骨密度的相关性分析 |
| The relationship between chronic obstructive pulmonary disease and bone mineral density in Chinese adults |
| Received:May 19, 2022 |
| DOI：10.3760/cma.j.cn112338-20220425-00341 |
| KeyWord: 慢性阻塞性肺疾病 慢性阻塞性肺疾病全球倡议分级 骨密度 |
| English Key Word: Chronic obstructive pulmonary disease Global Initiative for Chronic Obstructive Lung Disease grade Bone mineral density |
| FundProject:国家自然科学基金（81941018，91846303）；国家重点研发计划（2016YFC0900500，2016YFC1303904）；中国香港Kadoorie Charitable基金 |
| Author Name | Affiliation | E-mail | | Shi Kexiang | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Zhu Yunqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China | yucanqing@pku.edu.cn | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China | | | Guo Yu | Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China | | | Pei Pei | Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China | | | Yang Ling | Medical Research Council Population Health Research Unit at the University of Oxford, Oxford Population Health, Oxford OX3 7LF, United Kingdom
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom | | | Du Huaidong | Medical Research Council Population Health Research Unit at the University of Oxford, Oxford Population Health, Oxford OX3 7LF, United Kingdom
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom | | | Chen Yiping | Medical Research Council Population Health Research Unit at the University of Oxford, Oxford Population Health, Oxford OX3 7LF, United Kingdom
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom | | | Chen Junshi | China National Center for Food Safety Risk Assessment, Beijing 100022, China | | | Chen Zhengming | Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom | | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China | | | for the China Kadoorie Biobank Collaborative Group | | |
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| Abstract: |
| 目的 探究我国成年男性和女性中慢性阻塞性肺疾病（COPD）与骨密度的关系。方法 利用中国慢性病前瞻性研究第二次重复调查的数据，采用线性回归分析COPD及慢性阻塞性肺疾病全球倡议（GOLD）分级与跟骨骨密度指标（宽带超声衰减、超声声速、强度指数）之间的相关性。结果 共纳入23 876名研究对象，男性COPD患病率为34.3%（3 130/9 125），女性COPD患病率为23.2%（3 416/14 751）。以健康男、女性为参照，男、女性COPD患者的宽带超声衰减、超声声速、强度指数均降低，男性对应的β值（95%CI）分别为-0.87（-1.37~-0.36）、-3.42（-5.42~-1.43）、-1.53（-2.34~-0.71），女性对应的β值（95%CI）分别为-0.66（-1.09~-0.23）、-2.24（-3.92~-0.55）、-1.06（-1.71~-0.40），男性中下降幅度更大（交互作用均P<0.05）。GOLD分级与宽带超声衰减、超声声速、强度指数呈负相关，且存在线性趋势（线性趋势检验均P<0.001）。亚组分析显示，男性年龄≥60岁、男性低体力活动水平者、男、女性非超重/肥胖者中COPD患者骨密度下降幅度更大。结论 COPD与骨密度呈负相关，应加强对COPD患者骨密度的关注，尤其应关注年龄大、体力活动水平低、非超重/肥胖的COPD患者。 |
| English Abstract: |
| Objective To investigate the relationship between chronic obstructive pulmonary disease (COPD) and bone mineral density (BMD) in Chinese male and female adults.Methods Linear regression models were used to analyze the correlations between COPD and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade concerning bone mineral density indices, including broadband ultrasound attenuation, speed of sound, and stiffness index, based on data from the second resurvey of China Kadoorie Biobank.Results Among 23 876 participants, the prevalence of COPD was 34.3% (3 130/9 125) in males and 23.2% (3 416/14 751) in females. Compared with healthy males and healthy females, broadband ultrasound attenuation, speed of sound, and stiffness index decreased in males and females with COPD, with β values (95%CI) of -0.87 (-1.37- -0.36), -3.42 (-5.42- -1.43) and -1.53 (-2.34- -0.71) in males and -0.66 (-1.09- -0.23), -2.24 (-3.92- -0.55), -1.06 (-1.71- -0.40) in females, respectively. The decrease was greater in males than females (all P for interaction <0.05). The GOLD grade of COPD was inversely correlated with all the three indices in a dose-response manner (all P for trend <0.001). Subgroup analysis showed that patients with COPD had a greater decrease in BMD in males whose ages were ≥ 60 years, males who were less physically active, and participants who were not overweight or obese.Conclusions COPD was negatively correlated with bone mineral density. More attention should be paid to the bone mineral density of patients with COPD, especially those with older age, less physical activity, or lower BMI. |
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