| 姚才良,杜福昌,徐耀初,洪立基,周家仪,叶本法,王敬良.吸烟与冠心病 162例1:2配对研究[J].Chinese journal of Epidemiology,1984,5(2):88-90 |
| 吸烟与冠心病 162例1:2配对研究 |
| The Relationship of Smoking to the Incidence of Coronary Heart Disease |
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| Abstract: |
| 本文报告了162例吸烟与冠心病的配对研究，结果表明：1.吸烟，尤其是大量吸烟（≥20支/天）与冠心病有关。2.当血清胆固醇≥250毫克%时，吸烟与冠心病关系非常密切（χ2=9.00，P<0.01，RR=3.11），而血清胆固醇<250毫克%时，吸烟与冠心病无关。3.吸烟组中，高密度脂蛋白胆固醇平均值为61.7毫克%，明显低于不吸烟组的65.1毫克%，差别有显著性（P<0.05）提示吸烟能降低HDL-C水平，促进冠心病的发生。 |
| English Abstract: |
The relationship of smoking to the incidence of coronary heart disease (CHD) was investigated on 162 cases of clinical CHD matched with 324 controlled subjects with a ratio of one to two.
The results showed that statistically significant correlation between smoking,especially heavy smoking (more than one pack per day), and CHD existed among those subjects whose serum cholesterol valves were 250 mg/dl or above,the correlation between smoking and CHD was markedly significant (χ2=9.0, P<0.01, RR=3.11). But in those whose serum cholesterol levels were lower than 250 mg/dl cigarette smoking was not closely related to increased risk of CHD.
Further investigation proved that the mean values of serum high density lipoprotein-cholesterol (61.5 mg/dl) of the smoking group were less than that (65.1 mg/dl) of nonsmoking group and the difference was statistically siguificante (P<0.05). So smoking might be a factor which could lower serum HDL-C and then accelerated the development of CHD. |
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