国产BRDⅡ株风疹疫苗起始免疫月龄的血清学研究

徐爱强; 宋立志; 郝淑珍; 王常银; 许青; 王爱莲

Abstract

徐爱强,宋立志,郝淑珍,王常银,许青,王爱莲.国产BRDⅡ株风疹疫苗起始免疫月龄的血清学研究[J].Chinese journal of Epidemiology,1997,18(3):156-159

国产BRDⅡ株风疹疫苗起始免疫月龄的血清学研究

A Serological Study on the Immunization Schedule at First Dose of Domestic BRD Ⅱ Strain Rubella Vaccine

Received:November 05, 1996

DOI：

KeyWord: 风疹疫苗血凝抑制抗体

English Key Word: Rubella vaccine HI antibody

FundProject:

Author Name	Affiliation
Xu Ai-qiang	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
Song Li-zhi	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
Hao Shu-zhen	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
王常银	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
许青	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
王爱莲	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014

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Abstract:

为科学制订国产BRDⅡ株风疹疫苗初次免疫程序，作者对268名6~18月龄组儿童初免风疹疫苗前后风疹血凝抑制（HI）抗体水平进行了血清学研究。结果表明：在6、7、8、9、12和18月龄组儿童中，风疹疫苗免前HI抗体的阴性率分别为100.00%、95.56%、93.02%、96.36%、97.96%和93.94%，几何平均滴度（GMT）分别为0.00、1.17、1.21、1.12、1.07和1.13.各级之间的差异无显著性意义（P>0.05）；初免风疹疫苗1个月后，其免疫成功率分别为97.67%、95.56%、97.67%、98.18%、97.96%和96.67%，GMT分别为110.71、197.02、155.32、177.63、192.92和142.17，各组之间的差异亦无显著性意义（P>0.05），且免前低滴度HI抗体对免疫应答结果无明显影响。另外，蓬莱、海阳两市儿童母亲风疹HI抗体的阳性率分别为85.59%和94.67%，其差异具有显著性意义（χ²=5.40，P<0.05）。鉴于上述结果及我国现行的儿童计划免疫程序，作者建议国产风疹疫苗的起始免疫月龄定为儿童出生后8月龄接种为宜。

English Abstract:

In order to develop a valid immunization schedule on the initial vaccination at different age of domestic BRD Ⅱ strain rubella vaccine,a total number of 268 children at the age of 6 to 18 months from Yantai city of Shandong Province,China were selected for the serological study on hemagglutination inhibition (HI) antibody level against rubella from August to October, 1995. The results showed that the negative rates of HI antibody among children of 6, 7,8, 9, 12 and 18 month olds before inoculation with rubella vaccine were 100.00%, 95.56%, 93.02%, 96.36%, 97.96%and 93.94% with geometric mean titers (GMTs)0.00, 1.17, 1.21, 1.12, 1.07 and 1.13,respectively. After one month of immunization with rubella vaccine,the positive rates and GMTs of HI antibody were 97.67%, 95.56%, 97.67%, 98.18%, 97.96%, 96.67% and 110.71, 197.02, 155.32,1 77.63, 192.92, 142.17, respectively. There was no significant difference on immuno-response to rubella vaccine in children regardless the previous titers. Taking these results together with the current vaccine immunization schedule for expanded programme on immunization (EPI) in China into consideration,the author recommended that the immunization schedule at first vaccination for BRD Ⅱ strain rubella vaccine should be started at 8 month olds.

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