| 孟庆和,王建华,王正伦,宁宪嘉.2型糖尿病合并脑梗死危险因素的配比病例对照研究[J].Chinese journal of Epidemiology,2001,22(3):208-211 |
| 2型糖尿病合并脑梗死危险因素的配比病例对照研究 |
| Astudy on the risk factors of cerebral infarction as complication of type 2 diabetes mellitu patients |
| Received:August 16, 2000 |
| DOI： |
| KeyWord: 糖尿病, 非胰岛素依赖型 脑梗塞 条件 logistic 回归 |
| English Key Word: Diabetes mellitu, non-insulin-dependent Cerebral infarction Conditional logistic regression |
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| Abstract: |
| 目的 探讨 2型糖尿病合并脑梗死危险因素。方法 应用 1∶1配比的病例对照研究方法。应用条件logistic回归模型对资料进行分析。结果 文化程度与 2型糖尿病合并脑梗死有关。患 2型糖尿病以后,适当加强体育锻炼和劳动强度较大可以减小脑梗死发生的危险性。高密度脂蛋白 (HDL C)越高,2型糖尿病合并脑梗死的危险性越小。血糖控制以后,也可以降低 2型糖尿病合并脑梗死的危险性。上述因素为保护性因素。盐摄入过多可增加 2型糖尿病合并脑梗死的危险性。打鼾使 2型糖尿病患者发生脑梗死的危险性增加。高血压是 2型糖尿病合并脑梗死独立的危险因素。房颤是 2型糖尿病合并脑梗死的重要危险因素。A型性格与 2型糖尿病合并脑梗死有关,显示 2型糖尿病发生脑梗死有明显的个性特征存在。高胰岛素血症是 2型糖尿病发生脑梗死的危险因素。低密度脂蛋白 (LDL C)、载脂蛋白a [Lp(a) ]、纤维蛋白原 (Fg)水平增高,可以增加 2型糖尿病合并脑梗死的危险性。研究未发现吸烟、饮酒、口服避孕药、妊娠中毒症、总胆固醇 (TC)、甘油三酯 (TG)、Apo B与 2型糖尿病合并脑梗死有关。结论 为了控制 2型糖尿病合并脑梗死应提倡适当加强体育锻炼,多食蔬菜,控制盐的过多摄入,控制血糖和血压以及高胰岛素血症。 |
| English Abstract: |
| Objective Cerebral infarction, a common acute cereovascular disease, is one of the main complications of type 2 diabetes mellitus ( DM ). This paper is to explore the risk factors of cerebral infarction among type 2 DM patients. Methods A pair-matched case-control study was carried out. Data was analyzed with conditional logistic regression. Results One hundred and ten type 2 DM patients with cerebral infarction and controls were selected respectively. Results showed that higher educational level and physical exercises lowered the risk of cerebral infarction among type 2 DM patients. Higher HDL-C and blood sugar under control could also lower the risk of developing cerebral infarction among type 2 DM patients. The above factors seemed to have protective functions. Excessive salt intake and snoring increased the risks of cerebral infarction development among type 2 DM patients. Hypertension served as an independent risk factor while atrial fibrillation and hyperinsulinemia were important risk factors. High LDL-C, Apo-A, Lp(a), Fg increased the risk of cerebral infarction among type 2 DM patients. The study did not discover the relationship of smoking, drinking, oral contraception, menstrual and obstetrical history,TC,TG,Apo-A and cerebral infarction among type 2 DM patients.Conclusion To prevent cerebral infarction among type 2 DM, measures need to be taken as control of salt intake;eating more vegetables;regular physical exercises;control of blood sugar,blood pressure and Hyperinsulinemia. |
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