| 韩存芝,石璟,杜丽莉,荆洁线,赵先文,田保国,田富国,刘秀英,张中书,张进.瘦素及瘦素受体基因多态性与乳腺癌的相关性研究[J].Chinese journal of Epidemiology,2007,28(2):136-140 |
| 瘦素及瘦素受体基因多态性与乳腺癌的相关性研究 |
| Association among Iipids, 1eptin and leptin receptor polymorphisms with risk of breast cancer |
| Received:February 23, 2006 |
| DOI： |
| KeyWord: 乳腺肿瘤 瘦素 瘦素受体基因多态性 |
| English Key Word: Breast neoplasms Lepitin Leptin receptor gene polymorphism |
| FundProject:山西省自然科学基金资助项目(2006011129) |
| Author Name | Affiliation | | Han Cun-zhi | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Shi Jing | 山西医科大学, 太原 030001 | | Du Li-li | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Jing Jie-xian | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Zhao Xian-wen | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Tian Bao-guo | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Tian Fu-guo | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Liu Xiu-ying | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Zhang Zhong-shu | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China | | Zhang Jin | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China |
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| Abstract: |
| 目的: 探讨瘦素及其瘦素受体基因多态性与乳腺癌发生的关系。方法: 采用PCR-RFLP对94例乳腺癌患者、128例健康对照者进行瘦素受体基因Gln223Arg多态性检测; ELISA分析法测定瘦素水平。结果: 乳腺癌组瘦素受体基因Gln223Arg的GG、GA和AA基因型表达频率分别为69.15%、17.02%和13.83%; 等位基因G和A为77.66%和22.34%与对照组82.03%、15.63%和2.34%及等位基因的89.84%和10.16%相比较, 差异有统计学意义(P=0.004, P=0.001)。乳腺癌组瘦素水平, 腰臀比(wHR)明显高于对照组, 差异均有统计学意义(P<0.01,P<0.001)。非条件logistic回归多因素分析表明, 瘦素受体基因多态性、瘦素水平及WHR升高, 与乳腺癌发生的相关危险度分别为: OR=4.87, 95% CI:1.30～18.22, P=0.019; OR=1.53, 95%CI:1.13～2.07, P=0.006; OR=3.68, 95%CI: 1.34～10.11, P=0.01l。结论: 瘦素受体基因Gln223Arg多态性、瘦素及WHR升高, 可能增加乳腺癌发生的风险性。 |
| English Abstract: |
| Objective: To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer. Methods: LEPR Gln223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay. Results: In univariate regression analyses. We found serum 1evel of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P<0.05-0.001, respectively). Through multivariable analyses, we found that inereased risk estimates for breast cancer were among those with 1eptin level (OR=1.53, 95% CJ: 1.13-2.07, P=0.006), LEPR Gin223Arg genotype(OR=4.87, 95% CI: 1.30-18.22, P=0.019), WHR( OR=3.68, 95% CI: 1.34-10.11, P=0.011). Conclusion: Results from this study suggested that LEPR Gln233Agr polymorphism the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer. |
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