| 张之伦,解晓华.关注肾综合征出血热职业暴露的危害[J].Chinese journal of Epidemiology,2007,28(7):719 |
| 关注肾综合征出血热职业暴露的危害 |
| Attention needs to be paid to the risks of occupational exposures to hemorrhagic fever with renal syndrome |
| Received:January 18, 2007 |
| DOI： |
| KeyWord: 肾综合征出血热 职业暴露 |
| English Key Word: Hemorrhagic fever with renal syndrome Occupational exposures |
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| Abstract: |
| 肾综合征出血热(HFRS)职业暴露主要是从事教学、科研等工作需要与大白鼠等实验动物接触的人员,从事HFRS现场流行病学调查和灭鼠的人员,饲养、销售、运送野鼠和大白鼠等实验动物的人员. |
| English Abstract: |
| Objective To identify the mortality-related factors in patients undergoing maintenance hemodialysis.Methods One hundred and seven long-term hemodialysis patients having suffered from chronic glomerulonephritis and received hemodialysis treatment in the hemodialysis center of the Friendship Hospital during February 1990 to February 2002 were selected to take part in a retrospective study. Survival analysis was done using Life Tables study. Cox regression analysis was used to find factors related to risk. Patients were divided into two groups according to the clinical value of the factors which showed statistical significance in Cox regression analysis. Survive rates were compared between two groups on Gehan test.Results Among the 107 patients, 22 died (15.3%)and 85 survived (84.7%)during the follow-up period. Cumulative survival rates of 5 years and 10 years were 79.91% and 64.36% respectively. Prognostic factors would include age (P 0.001), blood urea nitrogen (BUN, P=0.004), serum creatinine (SCr, P=0.001), value of plasma calcium multiplied by plasma phosphate (P=0.019), and KT/V (P=0.001), which were all tested during the third dialysis month. The Hazard Ratios (HR) were 1.107 (95% Confidence Interval,95% CI : 1.049- 1.168), 0.951(95% CI : 0.918- 0.984), 0.727(95% CI : 0.599- 0.883), 1.025(95% CI : 1.004- 1.046), and 0.013(95% CI : 0.001- 0.161), respectively. The survival rates between two groups were significant different (age≥60 years group vs 60 years group P=0.000 6, BUN≥ 28.6 mmol/L vs 28.6 mmol/L group P=0.041 5, SCr≥884 μmol/L vs 884 μmol/L group P=0.014 6, value of plasma calcium multiplied by plasma phosphate ≥40 vs 40 group P=0.046 4, KT/V≥ 1.30 vs 1.30 group P=0.021 5).Conclusions The mortality related prognostic factors of maintained hemodialysis patients seemed to include age, BUN, SCr, value of plasma calcium multiplied by plasma phosphate, and KT/V, which were all tested during the third dialysis month. Among them, age and the value of plasma calcium multiplied by plasma phosphate were risk factors of death, while the others were protective factors. |
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