| 弟娟娟,王金桃,丁玲,王志敏,高尔生.还原叶酸载体基因多态性与宫颈癌关系的病例对照研究[J].Chinese journal of Epidemiology,2009,30(2):189-191 |
| 还原叶酸载体基因多态性与宫颈癌关系的病例对照研究 |
| A case-control study on the assodation of RFC-1 polymorphism and cervical cancer |
| Received:June 26, 2008 |
| DOI： |
| KeyWord: 宫颈肿瘤 病例对照研究 RFC-1基因多态性 |
| English Key Word: Cervical neoplasms Case-control study RFC-1 polymorphism |
| FundProject:山西省自然科学基金资助项月(2008011075-1) |
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| Abstract: |
| 探讨叶酸代谢相关酶基因还原叶酸载体基因(RFC-1)多态性与宫颈癌易感性的关系以及与人乳头瘤病毒(HPV)16在宫颈癌发生中的交互作用。方法采用以医院为基础的频数匹配病例对照研究，选择经病理学确诊的宫颈鳞状细胞癌新发病例107例作为病例组，子宫肌瘤患者107例作为对照组，应用特异性PCR和限制性片段长度多态性(RFLP)分别检测HPV16及RFC-1基因A80G多态性。 |
| English Abstract: |
| evaluate the possible association between RFC-1 polymorphism and cervix carcinoma.as well as the interaction between polymorphism and human papilloma virusl6(HPV16).Methods Based on a hospital-based case-control study.107 cases which were diagnosed as cervical cancer pathematologically and 107 controls with hysteromyoma,were selected by frequency,matched with age and habitation.HPV16 and RFC-1 A80G polymorphism were detected by special PCR and RFLP Results (1)HPV16 infection rate in CaseS(56.07%)Was higherthan that in controls(31.78%)with the adjusted OR with RFC-1 AA,RFC-1 GG had higher risk for cervical cancer with OR of2.42(95%CI:1.01-5.81).(4)No statistical significance was noticed regarding the interaction between RFC-l polymorphism and HPV16 in logistic regression method.Conclusion The introduction of RFC-1 80GG gene type could increase the risk of cervical cancer. |
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