HBV、HCV感染和XPC基因Ala499Val、Lys939Gln与肝癌关系的1：1匹配病例对照研究

蔡旭玲; 郜艳晖; 余卓文; 吴兆权; 周卫平; 杨翌; 许雅; 宋韶芳; 陈思东

Abstract

蔡旭玲,郜艳晖,余卓文,吴兆权,周卫平,杨翌,许雅,宋韶芳,陈思东.HBV、HCV感染和XPC基因Ala499Val、Lys939Gln与肝癌关系的1：1匹配病例对照研究[J].Chinese journal of Epidemiology,2009,30(9):942-945

HBV、HCV感染和XPC基因Ala499Val、Lys939Gln与肝癌关系的1：1匹配病例对照研究

A 1：1 matehed case．eontrol study on the interaction between HBV。HCV infection and DNArepair gene XPC Ala499Val，Lys939GIn for primary hepatocellular carcinoma

Received:March 07, 2009 Revised:September 20, 2007

DOI：

KeyWord: 发性肝癌 XPC基因多态性乙型肝炎病毒感染丙型肝炎病毒感染交互作用

English Key Word: mary hepatocellular carcinoma xPc gene polymorphisms Hepatitis B virus infection Hepatitis Cvirus infection Interaction

FundProject:国家自然科学基金青年基金(30500421)

Author Name	Affiliation	E-mail
CAI Xuling	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China	chensidong@tom．com
GA0 Yanhui	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China
YU Zhuowen	佛山市顺德区慢性病防治中心
WU Zhaoquan	佛山市顺德区慢性病防治中心
ZHOU Weiping	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China
YANG Yi	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China
XU Ya	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China
SONG Shaofang	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China
CHEN Sidong	Public Health College. Guangdong Collage of Pharmacy. Guangzhou 510310 China	Med_bp@zju.edu.cn

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Abstract:

目的探讨环境因素HBV、HCV感染与DNA修复基凶XPC第8外显子Ala499Val、第15外显子Lys939Gln交互作用在原发性肝癌(肝癌)发生中的作用。方法在广东省顺德地区采用1：1匹配的病例对照研究，PCR技术检测Ala499Val、Lys939Gln基因型，条件logistic回归分析环境与基因单独作用和交互作用对肝癌的影响。结果HBsAg阳性者中，无携带Ala499Val突变型基因者和至少携带一个突变型基因者的OR值分别为3．768(95％CI：1．137～12．485)和3．667(95％C1：1．122-11．981)；无携带Lys939Gln突变型基因者和至少携带一个突变型基因与肝癌关联的OR值分别为6．778(95％CI：2．025。22．688)和3．152(95％CI：1．062～9．351)。HCV感染者中，无携带Ala499Val突变型基因和至少携带一个突变型基因的OR值为2．955(95％C1：0．587～14．869)和1．085(95％CI：0．307-3．839)；携带至少一个突变型基因和无携带Lys939Gln突变型基因相比，OR值由4．197(95％C1：0．870～20．243)降低为0．887(95％CI：0．228～3．448)。但基于相乘模型的基因和环境交互作用均未达到统计学意义。结论携带Ala499Val突变型基因有降低HCV感染者的肝癌发病风险的趋势；而携带Lys939Gln突变型基因对HBV感染者和HCV感染者的肝癌发病风险都有降低的趋势，需要加大样本量进一步研究。

English Abstract:

Objective To evaluate the interaction between environmental factors，HBV／HCV infections and DNA repair gene XPC exon 8 Ala499Val。exon l 5 Lys939Gln on relatedrisks to primary hepatocellular cal'cinoma(PHC)．Methods A l：l matched case-control study was conducted in Shunde city，Guangdong province．The genotypes of Ala499Val and Lys939Gln were detected by polymerase ehain reaction restrictive fragment length polymorphism(PCR-RFLP)analysis．and gene．environment interactions were analyzed by conditionallogistic regression．ResultsAmong people infected by HBVwith non-or at least one mutant gene of Ala499Vm carriers．the risk of PHC significantly increased,With ORs as 3．768(95％CI：1．137-12．485)and 3．667(95％CI：1．122-11．981)respectively．With non．or at least one mutant gene of Lys939Gin．the risk was increasingwith 0Rs as 6．778(95％CI：2．025-22．688)and 3．152(95％CI．062-9．351)respectively．In those with HCV infection，non．or at 1east one mutant gene of Ala499Val might increase the risk with f)Rs as 2．955 (95％Ci：0．587-14．869)，1．085(95％CI：0．307-3．839)respectively．However，when compared to theones with no mutant gene of Lys939Gin among the same research subjects．thoge carrying at leastone genemaydecreasethe risk.with OR lowered from4．197(95％Ci：0．870-20．243)to 0．887(95％CI：0．228-3．448)．But the interactions between船V infection．HCV infection andⅫC genes were notstatistically significant．Conclusion Among people infected by HCV．the mutant gene ofMa499Ⅷhad the tendency to lower the risk of P’HC，and the mutant gene of Lys939GIn also appeared the same in the population with either HBV infecfion or HCV infection in Shunde．Guangdong．Another study with large samples should be performedto analyze the interactions among environments-genes．

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