河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析

刘佳; 樊盼英; 薛秀娟; 孙国清; 刘春华; 田随安; 李洁; 李宁; 孙定勇; 朱谦; 王哲

Abstract

刘佳,樊盼英,薛秀娟,孙国清,刘春华,田随安,李洁,李宁,孙定勇,朱谦,王哲.河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析[J].Chinese journal of Epidemiology,2015,36(11):1269-1273

河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析

Prevalence of hepatitis C virus antibody among newly reported HIV infection cases in Henan, 2012-2014

Received:March 19, 2015

DOI：10.3760/cma.j.issn.0254-6450.2015.11.017

KeyWord: 艾滋病病毒丙型肝炎病毒抗体新报告

English Key Word: HIV Anti-HCV New report

FundProject:河南省医学科技攻关计划项目(201404045);河南省重点科技攻关计划项目(142102310076);国家科技重大专项(2012ZX10004905-001-003)

Author Name	Affiliation	E-mail
Liu Jia	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Fan Panying	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Xue Xiujuan	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Sun Guoqing	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Liu Chunhua	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Tian Suian	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Li Jie	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Li Ning	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Sun Dingyong	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Zhu Qian	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Wang Zhe	Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China	wangzhe@hncdc.com.cn

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Abstract:

目的了解河南省2012－2014年新报告HIV感染者中HCV抗体的流行情况。方法通过艾滋病综合防治数据信息管理系统对河南省2012年7月1日至2014年6月30日新报告的HIV感染者进行信息整理、HIV-1 BED新发感染检测和HCV抗体检测。结果 4 267例新报告HIV感染者中HCV抗体阳性率为13.19%(563/4 267),感染途径为注射吸毒者的HCV抗体阳性率最高(77.27%),采血浆/输血、异性性传播、同性性传播和母婴传播人群的HCV抗体阳性率分别为15.06%、15.81%、3.74%和8.96%。开封(32.04%)、驻马店(25.00%)、商丘(25.00%)、周口(18.86%)和南阳(14.67%)为HCV抗体阳性率最高的前五个省辖市。BED阳性者(HIV新近感染者)中HCV抗体阳性率为7.50%(86/1 146)。多因素logistic回归分析发现:BED阴性、年龄>40岁、农民、HIV感染途径为注射吸毒以及报告地区为开封市、南阳市、商丘市、驻马店市和周口市为HCV感染的危险因素。结论 2012－2014年河南省新报告HIV感染者中HCV抗体流行率有降低的趋势,但是部分地区和重点人群仍存在较高的HCV抗体流行率。

English Abstract:

Objective To study the prevalence of antibody to hepatitis C virus (anti-HCV) among newly reported HIV infection cases in Henan province,2012-2014. Methods HIV-1 BED incidence test and anti-HCV test were conducted in newly diagnosed HIV infection cases in Henan, which were reported through national AIDS information system between 1 July 2012 and 30 June 2014. Results The data of 4 267 newly reported HIV-1 infection cases were analyzed, the positive rate of anti-HCV was 13.19% (563/4 267). The anti HCV was highest in those infected with HIV through injection drug use (77.27%), the anti-HCV positive rates in those infected with HIV through blood donation/transfusion, heterosexual contact, homosexual contact and mother-to-child transmission were 15.06%, 15.81%, 3.74% and 8.96%, respectively. Kaifeng (32.04%), Nanyang (14.67%), Shangqiu (25.00%), Zhumadian (25.00%) and Zhoukou(18.86%) were the first five prefectures with the high anti-HCV positive rates. The anti-HCV positive rate in BED positive patients (recent HIV-1 infections) was 7.50% (86/1 146). The multivariate logistic regressions analysis revealed that BED negative, aged >40 years, being farmer, HIV infection though injection drug use and living in in Kaifeng, Nanyang, Shangqiu, Zhumadian and Zhoukou were the risk factors for HCV infection. Conclusion The positive rate of anti-HCV declined between 2012-2014 in newly reported HIV infection cases in Henan, but the positive rate of anti-HCV was high in risk population and in some areas.

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