| 杨少萍,赵瑾珠,梅红,彭安娜,梅慧,谭亚飞,张丹,张艳,曹江霞,李瑞珍,周倩,雷凤琼,王芳,李娜,何正慧,姬云,曾丽敏,崔婧,张斌.武汉双生子出生队列研究[J].Chinese journal of Epidemiology,2018,39(9):1281-1286 |
| 武汉双生子出生队列研究 |
| The Wuhan Twin Birth Cohort Study |
| Received:April 18, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2018.09.026 |
| KeyWord: 双生子 出生队列 |
| English Key Word: Birth cohort Twin study |
| FundProject: |
| Author Name | Affiliation | E-mail | | Yang Shaoping | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zhao Jinzhu | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Mei Hong | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Peng An'na | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Mei Hui | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Tan Yafei | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zhang Dan | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zhang Yan | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Cao Jiangxia | Department of Maternal Healthcare, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Li Ruizhen | Department of Child Healthcare, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zhou Qian | Delivery Room, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Lei Fengqiong | Operating Room, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Wang Fang | Laboratory, Delivery, Recovery, Postpartum Ward, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Li Na | Obstetrics ⅡWard, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | He Zhenghui | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Ji Yun | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zeng Limin | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Cui Jing | Guiding Department for General Staff, Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | | | Zhang Bin | Wuhan Children' Hospital(Wuhan Maternal and Child Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China | 2500070378@qq.com |
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| Abstract: |
| 儿童及青少年期生长发育及心理行为相关疾病患病率有逐年上升趋势，且病因复杂。双生子共享母体宫内环境、同时出生并享有相同的早期家庭环境，能控制年龄、遗传和早期家庭环境等的干扰，是开展复杂慢性疾病研究的良好资源。利用双生子家庭开展出生队列研究，能更好地结合遗传和环境因素寻找复杂慢性疾病的病因起源。本研究从研究目标、内容、进展和优势与潜在问题等方面对武汉双生子出生队列进行简要介绍，着重呈现本研究的总体设计和进展概况。 |
| English Abstract: |
| The prevalence of child and adolescent growth and mental-behavior related diseases are increasing, and the pathogenesis are complex. Twins are excellent natural resources for complex chronic diseases research as they share the maternal intrauterine environment, born at the same time and share the same family environment in early years, which could benefit the adjust ment of confounding factors, such as age, genetic factors and early family environmental factors. Birth cohort with twin families involved could be more effective in exploring the genetic and environmental factors for complex chronic diseases at the very beginning of life. This paper summarizes the objective, content, progress, strengths and potential problems of Wuhan Twin Birth Cohort, with emphasis on the overall design and progress of the study. |
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