| 巫晶晶,黄鹏,岳明,汪春晖,吴超,邵建国,薛红,符祖强,卓凌云,喻荣彬,张云.TNFRSF11A和TNFRSF11B基因多态性与HCV感染转归的关系[J].Chinese journal of Epidemiology,2019,40(10):1291-1295 |
| TNFRSF11A和TNFRSF11B基因多态性与HCV感染转归的关系 |
| Association between TNFRSF11A and TNFRSF11B gene polymorphisms and the outcome of hepatitis C virus infection |
| Received:November 09, 2018 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.10.022 |
| KeyWord: 丙型肝炎病毒 基因多态性 肿瘤坏死因子受体超家族成员11A 肿瘤坏死因子受体超家族成员11B |
| English Key Word: Hepatitis C virus Gene polymorphism Tumor necrosis factor receptor superfamily members 11A Tumor necrosis factor receptor superfamily members 11B |
| FundProject:国家自然科学基金（81773499，81703273，81502853）；江苏省自然科学基金（BK20171054，BK20151026） |
| Author Name | Affiliation | E-mail | | Wu Jingjing | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Huang Peng | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Yue Ming | Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China | | | Wang Chunhui | Eastern Theater Command Center for Disease Prevention and Control, Nanjing 210002, China | | | Wu Chao | Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Shao Jianguo | Department of Gastroenterology, The Third People's Hospital of Nantong Affiliated to Nantong University, Nantong 226001, China | | | Xue Hong | Fourth Ward, The Third People's Hospital of Nantong Affiliated to Nantong University, Nantong 226001, China | | | Fu Zuqiang | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Zhuo Lingyun | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Yu Rongbin | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China | rongbinyu@njmu.edu.cn | | Zhang Yun | Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Eastern Theater Command Center for Disease Prevention and Control, Nanjing 210002, China | zhangyunvip@126.com |
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| Abstract: |
| 目的 探索肿瘤坏死因子受体超家族成员11A（TNFRSF11A）和11B（TNFRSF11B）基因多态性与丙型肝炎病毒（HCV）感染转归的关系。方法 以2008－2016年纳入的749例持续感染者、494例自限清除者和1 486例对照者作为研究对象开展病例对照研究，利用TaqMan-MGB探针法检测TNFRSF11A rs1805034和TNFRSF11B rs2073617两个位点的基因型，分析它们在不同人群中的分布情况。结果 共显性模型结果显示，与携带TNFRSF11B rs2073617 TT基因型的个体相比，携带CC基因的个体易发生HCV感染慢性化（OR=1.517，95% CI：1.055～2.181，P=0.024）。隐性模型结果显示，与携带rs2073617 TT或TC基因型的个体相比，携带CC基因的个体易发生HCV感染慢性化（OR=1.435，95% CI：1.033～1.996，P=0.032）；相加模型显示，随着携带C等位基因个数的增加，个体发生HCV感染慢性化的风险亦可增加（OR=1.204，95% CI：1.013～1.431，P=0.035）。结论 TNFRSF11B rs2073617的基因多态性与HCV感染慢性化可能存在关联。 |
| English Abstract: |
| Objective To explore the relationship between the tumor necrosis factor receptor superfamily members 11A (TNFRSF11A) and 11B (TNFRSF11B) gene polymorphisms and the outcome of hepatitis C virus (HCV) infection. Methods In this case-control study, 749 cases of persistent HCV infection, 494 cases of spontaneous clearance and 1 486 control subjects were included from 2008 to 2016. TaqMan-MGB probe method was used to detect the genotype of TNFRSF11A rs1805034 and TNFRSF11B rs2073617. The genotypes distribution of the two single nucleotide polymorphisms (SNP) were analyzed in different populations. Results Co-dominant model showed that individuals carrying the rs2073617 CC genotype were prone to have chronic HCV infection, compared with individuals carrying the rs2073617 TT genotype (OR=1.517, 95%CI:1.055-2.181, P=0.024). Recessive model results showed that individuals carrying rs2073617 CC genotype were more likely to develop chronic HCV infection compared with individuals carrying rs2073617 TT or TC genotype (OR=1.435, 95%CI:1.033-1.996, P=0.032). Additive model showed that the risk for chronic HCV infection increased with the increase of the number of rs2073617 C alleles (OR=1.204,95%CI:1.013-1.431, P=0.035). Conclusion The genetic polymorphism of TNFRSF11B rs2073617 might be related with the chronicity of HCV infection. |
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