| 王富珍,孙校金,王锋,刘建华,张国民,郑徽,缪宁,张爽,张伟,毕胜利,崔富强,沈立萍,梁晓峰.我国2014年1~29岁人群戊型肝炎血清流行病学特征分析[J].Chinese journal of Epidemiology,2019,40(11):1426-1431 |
| 我国2014年1~29岁人群戊型肝炎血清流行病学特征分析 |
| Sero-epidemiological characteristics of hepatitis E in population aged 1-29 years in China, 2014 |
| Received:March 07, 2019 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.11.016 |
| KeyWord: 戊型肝炎 血清学 流行病学特征 |
| English Key Word: Hepatitis E Serology Epidemiologic characteristic |
| FundProject:中国CDC公共卫生应急反应机制的运行（131031001000150001） |
| Author Name | Affiliation | E-mail | | Wang Fuzhen | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Sun Xiaojin | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Wang Feng | Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Liu Jianhua | Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China | | | Zhang Guomin | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Zheng Hui | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Miao Ning | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Zhang Shuang | Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Zhang Wei | Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Bi Shengli | Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Cui Fuqiang | School of Public School, Peking University Health Science Center, Beijing, 100191, China | | | Shen Liping | Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | shenlp@ivdc.chinacdc.cn | | Liang Xiaofeng | Chinese Center for Disease Control and Prevention, Beijing 102206, China | liangxf@chinacdc.cn |
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| Abstract: |
| 目的 分析2014年1~29岁人群戊型肝炎病毒（HEV）抗体（抗-HEV）的流行病学特征。方法 基于2014年我国1~29岁人群乙型肝炎血清流行病学调查个案数据库，估算样本量，采用单纯随机抽样法和随机函数抽取研究对象的血清标本，采用ELISA法检测抗-HEV IgG。运用SAS 9.1.3软件统计分析，采用抽样权重运用泰勒级数线性法计算不同年龄、性别、城乡、地区等抗-HEV阳性率及95%CI，通过比较95%CI判定差异是否有统计学意义。结果 共检测1~29岁人群血清标本14 106人，其中男性6 996人（49.60%），城市7 013人（49.72%）。我国1~29岁人群抗-HEV阳性率为8.12%（95%CI：7.19~9.15），男性和女性间、城市和农村之间差异无统计学意义；西部地区（11.36%，95%CI：9.45~13.62）高于东部和中部地区；1~、5~、10~、15~、20~和25~29岁组人群抗-HEV阳性率分别为2.46%、2.24%、4.50%、7.58%、11.89%、17.27%，随着年龄的增大，抗-HEV阳性率逐渐上升；不同民族抗-HEV阳性率较高的为藏族（18.32%，95%CI：12.02~26.90）、壮族（9.54%，95%CI：4.33~19.73）。结论 2014年我国抗-HEV阳性率有所下降，仍需密切关注1~29岁人群HEV感染、发病及相关危险因素。 |
| English Abstract: |
| Objective To analyze the epidemiological characteristics of hepatitis E Virus antibody (anti-HEV) in people aged 1-29 years in China in 2014. Methods Based on database of the national serologic survey of hepatitis B in people aged 1-29 years in China, in 2014, the sample size was estimated. The serum samples of the people surveyed were randomly selected to detect anti-HEV IgG by using enzyme-linked immunosorbent assay (ELISA). Statistical software SAS 9.1.3 was used to calculate the positive rate of anti-HEV and 95% confidence interval (CI) in different age, gender groups, urban and rural areas and geographic areas by using the Taylor series linear method with sampling weight. The difference was determined by comparing 95%CI. Results A total of 14 106 serum samples were detected from people aged 1-29 years, including 6 996 males (49.60%), 7 013 urban residents (49.72%). The positive rate of anti-HEV was 8.12%(95%CI:7.19-9.15) in people aged 1-29 years. There was no statistical difference between the men and women, between urban area and rural area. The positive rates of anti-HEV in western area (11.36%, 95%CI:9.45-13.62) was higher than those in eastern and central areas. The positive rates of anti-HEV were 2.46%, 2.24%, 4.50%, 7.58%, 11.89% and 17.27% in people aged 1-, 5-, 10-, 15-, 20- and 25-29 years, respectively. As the age increased, the positive rate of anti-HEV gradually increased. In different ethnic groups, the positive rate of anti-HEV was higher in Tibetan (18.32%, 95%CI:12.02-26.90), Zhuang (9.54%, 95%CI:4.33-19.73) ethnic groups. Conclusion The positive rate of anti-HEV declined slightly in China in 2014. It is still necessary to pay close attention to the HEV infection, morbidity of hepatitis E and risk factors in people aged 1-29 years. |
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