中国乳腺癌专病队列研究：人群队列研究方法及基线特征

包鹤龄; 刘丽媛; 方利文; 丛舒; 付振涛; 唐俊利; 杨珊; 史卫卫; 范敏; 曹民权; 郭晓雷; 孙纪新; 耿翠芝; 段学宁; 余之刚; 王临虹

Abstract

包鹤龄,刘丽媛,方利文,丛舒,付振涛,唐俊利,杨珊,史卫卫,范敏,曹民权,郭晓雷,孙纪新,耿翠芝,段学宁,余之刚,王临虹.中国乳腺癌专病队列研究：人群队列研究方法及基线特征[J].Chinese journal of Epidemiology,2020,41(12):2040-2045

中国乳腺癌专病队列研究：人群队列研究方法及基线特征

The Breast Cancer Cohort Study in Chinese Women: the methodology of population-based cohort and baseline characteristics

Received:May 07, 2020

DOI：10.3760/cma.j.cn112338-20200507-00695

KeyWord: 乳腺癌队列风险

English Key Word: Breast cancer Cohort Risk

FundProject:国家重点研发计划（2016YFC0901300，2016YFC0901301）

Author Name	Affiliation	E-mail
Bao Heling	National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Liu Liyuan	The Second Hospital of Shandong University, Ji'nan 250033, China
Fang Liwen	National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Cong Shu	National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Fu Zhentao	Shandong Center for Disease Control and Prevention, Ji'nan 250014, China
Tang Junli	Shandong Center for Disease Control and Prevention, Ji'nan 250014, China
Yang Shan	The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050019, China
Shi Weiwei	Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China
Fan Min	Taixing Center for Disease Control and Prevention, Taizhou 225400, China
Cao Minquan	Taixing Center for Disease Control and Prevention, Taizhou 225400, China
Guo Xiaolei	Shandong Center for Disease Control and Prevention, Ji'nan 250014, China
Sun Jixin	Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China
Geng Cuizhi	The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050019, China
Duan Xuening	Breast Disease Center, Peking University First Hospital, Beijing 100034, China
Yu Zhigang	The Second Hospital of Shandong University, Ji'nan 250033, China
Wang Linhong	National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China	wanglinhong@ncncd.chinacdc.cn

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Abstract:

目的乳腺癌在女性癌症中发病率第一且逐年上升。2016年9月，国家重点研发计划精准医学研究中国乳腺癌专病队列项目启动，旨在整合队列资源、提高随访质量、构建标准共享的乳腺癌专病队列，为实现乳腺癌发现、预防、早诊、治疗及预后研判等提供研究基础与标准化数据共享平台。方法本研究基于社区人群，采用询问调查、身体测量、生物样本采集、乳腺超声和钼靶X线检查建立前瞻性队列，采用区域健康监测和定向监测随访队列。结果整合乳腺癌专病社区人群队列112 118人，其中完成55 419人标准化队列调查，54 304人采集生物样本。平均年龄51.7岁，超重/肥胖女性占62.7%，绝经女性占48.9%。结论本研究将为中国女性乳腺癌精准防治提供队列基础和研究平台。

English Abstract:

Objective Breast cancer has been the first cancer among women with the incidence increasing gradually. In September 2016, the Breast Cancer Cohort Study in Chinese Women (BCCS-CW) was initiated, aiming to establish a standardized and sharable breast cancer-specific cohort by integrating the existing cohort resource and improving the quality of follow-up. The BCCS-CW may provide a research basis and platform for the precision prevention and treatment of breast cancer in etiology identification, prevention, early diagnosis, treatment, and prognosis prediction. Methods We conducted a population-based perspective cohort by questionnaire interview, anthropometry, biological specimens, breast ultrasound and mammography. The cohort was followed by using regional health surveillance and ad hoc survey. Results Finally, BCCS-CW included 112 118 women, in which 55 419 women completed the standardized investigation and blood specimens were collected from 54 304 women. The mean age of participants was 51.7 years old, 62.7% were overweight or obese, and 48.9% were menopausal. Conclusion The BCCS-CW will provide population-based cohort resource and research platform for the precise prevention and treatment of breast cancer in Chinese women.

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