| 李聿蕙,刘蕾,胡丹,郑晓艳,吕筠,余灿清,裴培,段海平,高汝钦,逄增昌,田小草,孙点剑一.青岛市成年人腰围与缺血性脑卒中发病风险关联的前瞻性研究[J].Chinese journal of Epidemiology,2024,45(2):178-184 |
| 青岛市成年人腰围与缺血性脑卒中发病风险关联的前瞻性研究 |
| Association between waist circumference and ischemic stroke: a prospective study in adults from Qingdao |
| Received:September 11, 2023 |
| DOI：10.3760/cma.j.cn112338-20230911-00146 |
| KeyWord: 缺血性脑卒中 腰围 前瞻性研究 |
| English Key Word: Ischemic stroke Waist circumference Prospective study |
| FundProject:国家自然科学基金（82192900，82192901，82192904，81390540，91846303，82103920）；国家重点研发计划（2023YFC2509400）；国家重点研发计划“精准医学研究”重点专项（2016YFC0900500）；中国香港Kadoorie Charitable基金；英国Wellcome Trust（202922/Z/16/Z，088158/Z/09/Z，104085/Z/14/Z）；青岛市医疗卫生优秀人才培养项目 |
| Author Name | Affiliation | E-mail | | Li Yuhui | Department of Epidemiology and Biostatistics, School of Public Health, Qingdao University, Qingdao 266071, China | | | Liu Lei | Department of Epidemiology and Biostatistics, School of Public Health, Qingdao University, Qingdao 266071, China | | | Hu Dan | Licang District Center for Disease Control and Prevention of Qingdao, Qingdao 266041, China | | | Zheng Xiaoyan | Licang District Center for Disease Control and Prevention of Qingdao, Qingdao 266041, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | | | Pei Pei | Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China | | | Duan Haiping | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Qingdao Institute of Preventive Medicine, Qingdao 266033, China | | | Gao Ruqin | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Qingdao Institute of Preventive Medicine, Qingdao 266033, China | | | Pang Zengchang | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Qingdao Institute of Preventive Medicine, Qingdao 266033, China | | | Tian Xiaocao | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Qingdao Institute of Preventive Medicine, Qingdao 266033, China | txc_2006911@126.com | | Sun Dianjianyi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | dsun1@bjmu.edu.cn |
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| Abstract: |
| 目的 分析腰围与缺血性脑卒中发病风险的关联。方法 研究对象来自中国慢性病前瞻性研究青岛项目点。利用研究对象的基线信息和随访获得的缺血性脑卒中发病事件，采用Cox比例风险回归模型和限制性立方样条图（RCS）模型分析腰围与缺血性脑卒中发病风险的关联。结果 共纳入研究对象33 355名，累计随访302 008.88人年，共有缺血性脑卒中新发病例1 093名。Cox比例风险回归模型分析结果显示，与腰围正常组（男性<85.0 cm/女性<80.0 cm）相比，腰围超标组（男性≥85.0 cm/女性≥80.0 cm）发生缺血性脑卒中的风险升高了78%［风险比（HR）=1.78，95%CI：1.51~2.10］，在男性和女性中分别升高了72%（HR=1.72，95%CI：1.40~2.12）和83%（HR=1.83，95%CI：1.40~2.39）。RCS模型分析显示，腰围与缺血性脑卒中发病风险呈非线性的“S”形剂量-反应关系。结论 缺血性脑卒中发病风险随着腰围的增加而增加，维持正常腰围对于预防缺血性脑卒中具有重要意义。 |
| English Abstract: |
| Objective To analyze the association between waist circumference (WC) and ischemic stroke (IS). Methods The data for the present study were from the prospective cohort study of China Kadoorie Biobank in Qingdao. Using baseline information and IS events of the participants, the Cox proportional hazard regression model and restricted cubic spline (RCS) were used to analyze the association between WC and IS. Results A total of 33 355 participants were included in the study, with 302 008.88 person-years of follow-up. A total of 1 093 new cases of IS were observed. Multivariate Cox proportional hazard regression model analysis showed that compared to the respondents with normal WC (male <85.0 cm, female <80.0 cm), respondents with excessive WC (male ≥85.0 cm, female ≥80.0 cm) had a 78% higher risk of IS incidence [hazard ratio(HR)=1.78, 95%CI: 1.51-2.10], and the risk increased by 72% (HR=1.72, 95%CI: 1.40-2.12) and 83% (HR=1.83, 95%CI: 1.40-2.39) in men and women. According to the RCS, the increase in WC and the risk of IS showed an "S" trend of nonlinear dose-response relationship. Conclusions The risk of IS would increase with the WC. Keeping a normal WC is important for preventing IS. |
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