| 刘凤琪,杨智荣,武珊珊,赵厚宇,詹思延,孙凤.效应修饰作用分析方法与案例解析系列（二）：网状Meta分析中的效应修饰[J].Chinese journal of Epidemiology,2024,45(2):273-278 |
| 效应修饰作用分析方法与案例解析系列（二）：网状Meta分析中的效应修饰 |
| Analysis methods and case analysis of effect modification (2): effect modification in network Meta-analysis |
| Received:August 24, 2023 |
| DOI：10.3760/cma.j.cn112338-20230824-00094 |
| KeyWord: 网状Meta分析 效应修饰作用 亚组分析 网状Meta回归 |
| English Key Word: Network Meta-analysis Effect modification Subgroup analysis Network Meta-regression |
| FundProject:国家自然科学基金（72074011） |
| Author Name | Affiliation | E-mail | | Liu Fengqi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | | | Yang Zhirong | School of Computer Science and Control Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China | | | Wu Shanshan | National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China | | | Zhao Houyu | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | | | Zhan Siyan | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | | | Sun Feng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China | sunfeng@bjmu.edu.cn |
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| Abstract: |
| 本文简要介绍网状Meta分析中效应修饰作用的特点、研究意义和现状，并通过图表展示了效应修饰作用在网状Meta分析中导致的异质性问题，强调在网状Meta分析中探索效应修饰作用的重要性，总结5个不同场景下效应修饰作用的规范化描述和分析策略。通过“3类新型降糖药降低2型糖尿病患者体重的疗效比较”这一实际案例展示了亚组分析和网状Meta回归在网状Meta分析中对效应修饰作用的探索，并对二者的优缺点及注意事项进行总结，旨在为未来研究者提供参考。 |
| English Abstract: |
| This paper briefly introduces the characteristics, research significance, and global reporting status of effect modification in network Meta-analysis, demonstrates the heterogeneity caused by effect modification in network Meta-analysis, and emphasizes the importance of exploring effect modification in network Meta-analysis. This paper also summarizes the normalized description and analysis strategies of effect modification in network Meta-analysis. Finally, by the case of "comparison of efficacy of three new hypoglycemic drugs in reducing body weight in type 2 diabetes patients", this paper demonstrates the realization of subgroup analysis and network Meta-regression in exploring effect modification, summarizes the advantages and disadvantages of the two methods, to provide references for future researchers. |
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