Abstract
刘凤琪,杨智荣,武珊珊,赵厚宇,詹思延,孙凤.效应修饰作用分析方法与案例解析系列(二):网状Meta分析中的效应修饰[J].Chinese journal of Epidemiology,2024,45(2):273-278
效应修饰作用分析方法与案例解析系列(二):网状Meta分析中的效应修饰
Analysis methods and case analysis of effect modification (2): effect modification in network Meta-analysis
Received:August 24, 2023  
DOI:10.3760/cma.j.cn112338-20230824-00094
KeyWord: 网状Meta分析  效应修饰作用  亚组分析  网状Meta回归
English Key Word: Network Meta-analysis  Effect modification  Subgroup analysis  Network Meta-regression
FundProject:国家自然科学基金(72074011)
Author NameAffiliationE-mail
Liu Fengqi Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China 
 
Yang Zhirong School of Computer Science and Control Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China  
Wu Shanshan National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China  
Zhao Houyu Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China 
 
Zhan Siyan Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China 
 
Sun Feng Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory of Epidemiology of Major Diseases(Peking University), Ministry of Education, Beijing 100191, China 
sunfeng@bjmu.edu.cn 
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Abstract:
      本文简要介绍网状Meta分析中效应修饰作用的特点、研究意义和现状,并通过图表展示了效应修饰作用在网状Meta分析中导致的异质性问题,强调在网状Meta分析中探索效应修饰作用的重要性,总结5个不同场景下效应修饰作用的规范化描述和分析策略。通过“3类新型降糖药降低2型糖尿病患者体重的疗效比较”这一实际案例展示了亚组分析和网状Meta回归在网状Meta分析中对效应修饰作用的探索,并对二者的优缺点及注意事项进行总结,旨在为未来研究者提供参考。
English Abstract:
      This paper briefly introduces the characteristics, research significance, and global reporting status of effect modification in network Meta-analysis, demonstrates the heterogeneity caused by effect modification in network Meta-analysis, and emphasizes the importance of exploring effect modification in network Meta-analysis. This paper also summarizes the normalized description and analysis strategies of effect modification in network Meta-analysis. Finally, by the case of "comparison of efficacy of three new hypoglycemic drugs in reducing body weight in type 2 diabetes patients", this paper demonstrates the realization of subgroup analysis and network Meta-regression in exploring effect modification, summarizes the advantages and disadvantages of the two methods, to provide references for future researchers.
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