Abstract
王静娴,殷玥琪,沈鹏,陈云鹏,林鸿波,王怡,孙烨祥.宁波市鄞州区2017-2022年6岁及以下儿童疱疹性咽峡炎流行特征及与手足口病发病的互相关分析[J].Chinese journal of Epidemiology,2024,45(5):714-720
宁波市鄞州区2017-2022年6岁及以下儿童疱疹性咽峡炎流行特征及与手足口病发病的互相关分析
Epidemiological characteristics of herpangina and its correlation with incidence of hand, foot and mouth disease in children aged 6 years and under in Yinzhou District of Ningbo, 2017-2022
Received:October 20, 2023  
DOI:10.3760/cma.j.cn112338-20231020-00239
KeyWord: 疱疹性咽峡炎  手足口病  流行特征  互相关
English Key Word: Herpangina  Hand,foot and mouth disease  Epidemiological characteristics  Cross correlation
FundProject:国家自然科学基金(91846303);北大百度基金-面向人群健康和重大疾病的大数据平台建设研究(2019BD010)
Author NameAffiliationE-mail
Wang Jingxian School of Public Health, Wenzhou Medical University, Wenzhou 325000, China  
Yin Yueqi Department of Data Center, Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315100, China  
Shen Peng Yinzhou Key Laboratory for Virus Detection in Ningbo, Ningbo 315100, China
Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315100, China 
shen-peng@foxmail.com 
Chen Yunpeng Department of Data Center, Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315100, China  
Lin Hongbo Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315100, China  
Wang Yi School of Public Health, Wenzhou Medical University, Wenzhou 325000, China wang.yi@wmu.edu.cn 
Sun Yexiang Department of Data Center, Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315100, China 19464337@qq.com 
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Abstract:
      目的 了解宁波市鄞州区2017-2022年≤6岁儿童疱疹性咽峡炎(HA)流行特征并分析其与手足口病(HFMD)发病的互相关性。方法 基于鄞州区域健康大数据平台2017-2022年的电子病历数据和公共卫生管理数据,分析≤6岁儿童HA流行特征。利用公共卫生管理数据中传染病报告数据计算HFMD发病率,采用自回归移动平均模型与互相关函数分析HA和HFMD发病的相关性。结果 2017-2022年鄞州区≤6岁儿童中累计监测HA病例25 385例,男女性别比为1.12∶1。HA年均发病率为4 986.67/10万,2018年最高(10 477.09/10万),2020年最低(870.88/10万)。HA发病高峰为6、7月,1岁组发病率高于其他年龄组,发病率为7 950.45/10万;云龙镇、姜山镇和下应街道发病率较高,发病率依次为8 764.31/10万、8 377.58/10万和7 965.31/10万。HA发病率与滞后0、7、12、18 d的HFMD发病率互相关系数分别为0.199、0.139、0.090、0.086(均P<0.05)。结论 2017-2022年鄞州区≤6岁儿童中HA呈高流行水平,发病率存在季节性和地区差异性,HA发病与HFMD发病存在相关性,且HFMD发病有一定滞后性。应重视HA监测,开展HA和HFMD的同期监测和管理,加强两者的综合防控。
English Abstract:
      Objective To investigate the epidemiological characteristics of herpangina (HA) and its correlation with the incidence of hand, foot and mouth disease (HFMD) in children aged ≤6 years in Yinzhou District of Ningbo from 2017 to 2022. Methods Epidemiological characteristics of HA in children aged ≤6 years were analyzed based on the electronic medical record data and public health management data from 2017 to 2022 collected from the Health Information Platform of Yinzhou. The incidence of HFMD was calculated using the infectious disease reporting data from the public health management data. Autoregressive integrated moving average model and cross-correlation function were used to evaluate the correlation between the incidence of HA and HFMD. Results From 2017 to 2022, a total of 25 385 cases of HA were detected in children aged ≤6 years in Yinzhou, the male-to-female ratio of the cases was 1.12∶1. The average annual incidence of HA was 4 986.67/100 000, with the highest incidence in 2018 (10 477.09/100 000) and the lowest incidence in 2020 (870.88/100 000). The incidence peak of HA was during June to July. The incidence of HA was higher in age group 1 year (7 950.45/100 000) than in other age groups. The incidences of HA in Yunlong, Jiangshan and Xiaying were higher, with the incidence of 8 764.31/100 000, 8 377.58/100 000 and 7 965.31/100 000, respectively. The correlation coefficients between the incidence of HA and HFMD at lag day 0, 7, 12 and 18 were 0.199, 0.139, 0.090 and 0.086, respectively (all P<0.05). Conclusions From 2017 to 2022, the incidence of HA was high in children aged ≤6 years in Yinzhou with obvious seasonality and area difference. The incidence of HA was correlated with the incidence of HFMD and the incidence of HFMD had certain lags. The comprehensive prevention and control of HA and HFMD should be further strengthened by prioritizing HA surveillance and implementing integrated surveillance and management of HA and HFMD.
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