天津市男男性行为人群多部位人乳头瘤病毒感染状况及相关因素分析

李慧娟; 柏建芸; 于茂河; 董笑月; 宁铁林; 朱静瑾; 张颖

Abstract

李慧娟,柏建芸,于茂河,董笑月,宁铁林,朱静瑾,张颖.天津市男男性行为人群多部位人乳头瘤病毒感染状况及相关因素分析[J].Chinese journal of Epidemiology,2024,45(12):1693-1699

天津市男男性行为人群多部位人乳头瘤病毒感染状况及相关因素分析

Analysis of human papillomavirus infection status and related factors among men who have sex with men in Tianjin

Received:June 17, 2024

DOI：10.3760/cma.j.cn112338-20240617-00355

KeyWord: 人乳头瘤病毒男男性行为人群感染状况相关因素

English Key Word: Human papillomavirus Men who have sex with men Infection status Related factors

FundProject:天津市医学重点学科(TJYXZDXK-050A);国家疾病预防控制局公共卫生人才培养支持项目

Author Name	Affiliation	E-mail
Li Huijuan	Tianjin Medical University, Tianjin 300070, China
Bai Jianyun	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China
Yu Maohe	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease, Tianjin 300011, China
Dong Xiaoyue	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China
Ning Tielin	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease, Tianjin 300011, China
Zhu Jingjin	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China
Zhang Ying	Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China	cdczhangying@sina.com

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Abstract:

目的分析天津市MSM多部位HPV感染状况及相关因素。方法采用横断面研究设计方法，于2023年9-12月在天津市招募MSM研究对象600人，按年龄组分层招募18~、27~和≥46岁分别为200、300和100人。采用问卷调查收集社会人口学、STD防治相关知识及行为学信息，采集生殖器、肛周和口腔部位脱落细胞进行HPV分型检测，采用logistic回归模型分析HPV感染的相关因素。结果天津市MSM的HPV感染率为53.67%（322/600），高危型和低危型HPV感染分别为41.17%（247/600）和27.17%（163/600），多重型别和单一型别的HPV感染率均为26.83%（161/600），九价/四价/二价HPV疫苗覆盖的HPV型别感染率分别为36.83%（221/600）、25.17%（151/600）、9.50%（57/600）。生殖器部位的HPV感染率为24.67%（148/600），高危型和低危型HPV感染率分别为16.67%（100/600）和11.00%（66/600）；肛周部位的HPV感染率为42.00%（252/600），高危型和低危型HPV感染率分别为30.17%（181/600）和20.50%（123/600）；口腔部位的HPV感染率为3.17%（19/600），高危型和低危型HPV感染率分别为2.33%（14/600）和1.17%（7/600）。生殖器部位感染HPV的危险因素包括离异/丧偶（aOR=2.38，95%CI：1.26~4.50）、最近6个月与同性发生肛交（aOR=2.28，95%CI：1.00~5.50）、吸食过依赖药物（aOR=1.62，95%CI：1.02~2.58）。肛周部位感染HPV的保护因素和危险因素分别为大专/大学及以上文化程度（aOR=0.36，95%CI：0.16~0.81）和吸食过依赖药物（aOR=1.85，95%CI：1.19~2.88）。结论天津市MSM是HPV感染的高危人群，生殖器、肛周和口腔部位HPV感染情况以肛周较为严重。婚姻状况、文化程度、最近6个月与同性发生肛交、吸食过依赖药物是MSM感染HPV的相关因素。

English Abstract:

Objective The status quo and related factors of human papillomavirus (HPV) infection in multiple parts of men who have sex with men (MSM) in Tianjin were analyzed. Methods Using the cross-sectional survey method, a total of 600 MSM were recruited in Tianjin from September to December 2023, including 200 (18-26 years old), 300 (27-45 years old), and 100 (≥46 years old) stratificaed by age group. Questionnaire survey was used to collect knowledge and behavioral information related to demography and STD prevention and treatment. Exfoliated cells from genital, perianal and oral cavity were collected for HPV typing detection. Logistic regression model was used to analyze the related factors of HPV infection. Results The infection rate of HPV was 53.67% (322/600) in MSM, with high-risk type as 41.17% (247/600), low-risk type as 27.17% (163/600). The infection rate of HPV in both multiple and single types was 26.83% (161/600).The infection rates of genotypes covered by nine-valent HPV vaccine, quadrivalent HPV vaccine and bivalent HPV vaccine were 36.83% (221/600), 25.17% (151/600) and 9.50% (57/600), respectively. The infection rates of genital HPV, high-risk or low-risk types were 24.67% (148/600), 16.67% (100/ 600) and 11.00% (66/600), respectively. The infection rates of perianal HPV, high-risk or low-risk types were 42.00% (252/600), 30.17% (181/600) and 20.50% (123/600), respectively. The infection rates of oral HPV high-risk and low-risk types were 3.17% (19/600), 2.33% (14/600) and 1.17% (7/600), respectively. Divorce or widowhood (aOR=2.38, 95%CI: 1.26-4.50), history of homosexual anal intercourse in the past 6 months (aOR=2.28, 95%CI: 1.00-5.50), and use of dependent drugs (including new psychoactive substances) (aOR=1.62, 95%CI: 1.02-2.58) were risk factors for genital HPV infection. College degree/university degree or above (aOR=0.36, 95%CI: 0.16-0.81) was a protective factor for perianal HPV infection, and a history of drug dependence (aOR=1.85, 95%CI: 1.19-2.88) was a risk factor. Conclusions MSM in Tianjin was a high-risk group for HPV infection, and the HPV infection in the perianal area was more severe than in the genital area and oral area. Marital status, education level, history of homosexual anal sex in the past 6 months, and history of drug dependence were related factors of HPV infection among MSM.

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