| 何忠虎,柯杨.中国癌症筛查科研与实践工作面临的挑战与应对策略：以食管癌为例[J].Chinese journal of Epidemiology,2024,45(12):1720-1725 |
| 中国癌症筛查科研与实践工作面临的挑战与应对策略：以食管癌为例 |
| Challenges and coping strategies of cancer screening research and practice in China: Taking esophageal cancer as an example |
| Received:May 24, 2024 |
| DOI：10.3760/cma.j.cn112338-20240524-00304 |
| KeyWord: 癌症筛查 癌症防治 挑战 应对策略 食管癌 |
| English Key Word: Cancer screening Cancer prevention and treatment Challenge Coping strategy Esophageal cancer |
| FundProject: |
| Author Name | Affiliation | E-mail | | He Zhonghu | State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Ke Yang | State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics, Peking University Cancer Hospital & Institute, Beijing 100142, China | keyang@bjmu.edu.cn |
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| Abstract: |
| 由于多数癌症的高风险归因的致病因素不明，一级预防缺少干预靶标。因此，我国癌症防治的重点已从病因学预防逐渐转向在大众人群中开展早期筛查，即早诊早治。本文以食管癌为例，提出我国当前在癌症筛查科研与实践工作中面临的主要挑战，包括：①癌症自然史的认知需进一步加强；②癌症筛查有效性和价值的高等级证据有限；③当前筛查模式的效率和精准度有待提升；④筛查实践的普惠性与可持续性不足。为有效应对这些挑战，提出可能的应对策略：①开展高质量人群和临床流行病学研究，建立并推广符合我国国情和需求的癌症防控新技术及新路径；②打破传统束缚，建立符合我国癌症防控一线需求、高效且精准的癌症筛查新策略、新模式；③搭建政府决策部门、科研团队和产业机构之间有效沟通的平台，共同推动癌症防控领域的协作与转化。通过多学科、多部门协同，实现我国癌症防治的远景目标。 |
| English Abstract: |
| For most cancers, clear intervention targets for primary prevention are lacking, due to unidentified high-risk causal factors. Consequently, the focus of cancer prevention and control in China has shifted towards early screening and treatment within the general population. This review outlines the significant challenges in research and practice of cancer prevention and control in China, including: ① inadequate understanding of the natural history of cancer; ② limited high-level evidence supporting cancer screening effectiveness and value; ③compromised efficiency and accuracy in current screening modality; and ④ insufficient universality and sustainability of the current screening practices, taking esophageal cancer as an example. To address these challenges, we propose potential coping strategies: ① establishing tailored technologies and pathways for cancer prevention and control based on population-based and clinical epidemiological studies using high-quality designs; ② breaking conventional constraints to establish a novel, efficient, and precision cancer screening strategy and modality that aligned with the frontline needs of cancer prevention and control; and ③establishing enhanced communication platforms among government policymaking departments, scientific research teams, and industrial institutions to foster collaboration and translation in the field of cancer prevention and control. Ultimately, through the collaboration of multiple disciplines and departments, we will jointly achieve the long-term goal of cancer prevention and treatment. |
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