| 泮作清,方金泉,徐金和.从母体围产期感染乙肝病毒的新生儿HBsAg携带状态及某些免疫指标观察[J].中华流行病学杂志,1983,4(4):223-225 |
| 从母体围产期感染乙肝病毒的新生儿HBsAg携带状态及某些免疫指标观察 |
| Observation of HBsAg-carrying Status of Newborn Infants Infected with Hepatitis B Virus from Their Mothers During Perinatal Period and Certain Immunological Parametqers |
| 收稿日期: 出版日期:2021-06-09 |
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| 中文摘要: |
| 本文报告7例来自母体HBV感染的婴儿,经三次乙肝抗原抗体检测及非特异性免疫功能检查。结果表明,分娩时HBsAg阴性;6个月时全部阳转,其GMT为1:86, HBeAg有4例阳性;30个月时仍持续阳性,其GMT为1:311, HBeAg有5例阳性。三次均未检出抗-HBs及抗-HBe。30个月时SGPT有3例超过25单位,其中1例高达145单位。以T和B为主的淋巴细胞花环形成率,实验组和对照组无显著差异。IgG、IeA、IgM两组也无显著差异。这表明本文HBsAg携带婴儿的非特异性免疫功能看不出有异常现象,对HBsAg的特异性抗体反应较差,可能是携带状态发生原因之一。 |
| 英文摘要: |
| In this paper 7 newborn perinatally infected with HBV were reported. They were examined 3 times for HBsAg, anti-HBs, HBeAg, and anti-HBe and cell-mediat'ed immune function.The results showed that HBsAg was negative in the cord blood but all became positive 6 months after birth with GMT of 1:86 and HBeAg was positive in 4 cases.Persistcntly positive reaction was found with GMT of 1:311 and HBeAg was positive in 5 cases 30 months after birth. Neither anti-HBs nor anti-HBe was found positive in all the three examinations. In three cases,serum GPT was over 25 units by the 30th month and the level reached as high as 145 units in one of them. No significant difference was observed between the children born to the HBsAg positive mothers and those of the control children born to HBsAg negative mothers in the rate of rosette formation comprised mainly of T-and B-lymphcytcs. The results of the level of IgG, IgA, IgM showed not much difference between the two groups. The results of the examination indicate that no abnormality was observed in the cell-mediated immune function in HBsAg carrier infants. One of the causes for their carrier state was probably their poorres ponses in thehumoral immune function against HBsAg. |
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