| 陈祖府,吴光财.一起伯氨喹啉药物性溶血反应的调查报告[J].中华流行病学杂志,1986,7(2):97-98 |
| 一起伯氨喹啉药物性溶血反应的调查报告 |
| A Survey of Hemolytic Reaction due to Administration of Drug-Amino-compound of Quinine |
| 收稿日期: 出版日期:2021-05-25 |
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| 中文摘要: |
| 本文报告了罗甸县某一布依族村庄1982年4月发生的一起伯氨喹啉药物性溶血反应的调查结果。576人服药,81人发生溶血,反应率14.06%,其中男性反应率(19.87%)明显高于女性(7.20%),而有近亲婚配家族的35人溶血29人,溶血发生率高达82.86%。81例溶血患者中75例红细胞G6PD有不同程度的缺乏,其溶血特征与之遗传特点相吻合,而未溶血者G6PD活性基本正常,表明该起溶血反应系由于体内遗传性红细胞G6P D缺陷所致。 |
| 英文摘要: |
A study of the haemolytic reaction due to primaquine in a Buyi nationality village of Luodian county, Guizhou province in April 1982 was reported.
It was found that 81 out of 576 persons developed haemolytic reaction after their administration of the medicine. The rate of such reaction was 14.06% and was significantly higher in male (19.87%) than female (7.20%). 29 patients who developed such a haemolytic manifestation were found to be of kinship marriage among 35 cases investigated with a rate of 82.86%.
G6PD of erythrocyte was found to be of causative factor probably owing to the fact that 75 out of 81 haemolytic patients were found to be running low of G6PD. Therefore, the. haemolytic occurrence fits well with the genetic feature. Meanwhile the activity of G6PD is normal among those nonhaemolytic people.
This suggests that the cause of the haemolytic reaction by primaquine may be due to the genetic deficiency of G6PD synthesized in erythrocyte. |
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