| 丁正荣,李荣成,龚健,冯永贞,陈琨琳,李艳萍,农远志,黎朝作,韦良典,李燕超.乙型肝炎与肝癌关系的流行病学研究—广西HBsAg携带者及肝损害者的分布及发生肝癌的前瞻性研究[J].中华流行病学杂志,1988,9(4):220-223 |
| 乙型肝炎与肝癌关系的流行病学研究—广西HBsAg携带者及肝损害者的分布及发生肝癌的前瞻性研究 |
| Epidemiological Study on Relationship between Hepatitis B and Liver Cancer—A Prospective Study on Development of Liver Cancer and Distribution of HBsAg Carriers and Liver Damage Persons in Guangxi |
| 收稿日期: 出版日期:2021-05-31 |
| DOI： |
| 中文关键词: HBsAg携带者 肝损害人群 追踪观察 相对危险性 肝癌死亡率 |
| 英文关键词: HBsAg carriers Liver danage Persons Follow-up Relative risk PLC death rate |
| 基金项目: |
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| 中文摘要: |
| 本文对20岁以上22830人按HBsAg状况和肝损害表现分队列进行随访,平均追踪6.8年,在肝癌高发区和低发区均以HBsAg携带者并有重度肝损害者(肝大+肝功能异常)的肝癌死亡率和相对危险性最高,相对危险性分别为37.3和22.5倍。以无肝大和肝功能异常的非携带者最低,肝癌的发生和肝损害的程度呈平行关系。HBsAg携带者发生肝癌死亡的相对危险性高于非携带者7倍,并发现HBsAg携带并有重度肝损害的肝癌死亡的平均年龄显著提前。认为肝癌高发区人群中HBV的持续感染和肝损害的广泛存在是导致肝癌高发和早发的重要因素。 |
| 英文摘要: |
| Twenty-two thousand eight hundred and thirty Persons aged over 20 years were divided into according to the HBsAg carrier and degree of liver damage and followed up for an average of 6.8 years per person. The relative risk and the death rate of primary liver cancer (PLC) in the HBsAg carriers with severe liver damage (hepatomegaly and biochemical abnormalities coexist) were the highest in the areas of the high and low incidence of PLC, the relative risk was 37.3 and 22.5, respectively. The relative risk and the death rate of PLC in the noncarriers without liver damage were the lowest. The occurrence of PLC was Parallel with the degree of liver damage. The relative risk of PLC was seven times higher in HBsAg carriers than that in non-carriers. The average of onset of PLC in HBsAg carriers with severe liver damage was considerably earlier and younger. It suggested that the persistent HBV infections and widespread distribution of liver damage in hyperendemic area of PLC were the factors of facilitating the higher and earlier development of PLC. |
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