文章摘要
乔友林,乔树民.卵巢癌高危险因素的病例—对照研究[J].中华流行病学杂志,1988,9(5):269-273
卵巢癌高危险因素的病例—对照研究
A Case-Control Study of High-Risk Factors in Ovarian Carcinoma
收稿日期:  出版日期:2021-06-01
DOI:
中文关键词: 病例-对照研究  卵巢癌
英文关键词: Case-control study  Ovarian carcinoma
基金项目:
作者单位
乔友林 大连医学院 
乔树民 大连医学院 
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中文摘要:
      本文对原发性卵巢上皮癌(卵巢癌)发病的高危险因素进行配对研究。共选用卵巢癌病例62例,对照124例。详细了解病例和对照的月经史、生育史、嗜好和某些病毒的感染情况等发现月经不规则,不育和孕次较少及流行性腮腺炎病毒感染可能与卵巢癌发病有关。怀孕次数少患卵巢癌的相对危险度较大。趋势性检验(2×c表),差别也显著(χ2=10.07,P<0.05)。提示妊娠可能是卵巢癌保护因素之一。对月经初潮、停经、初产和结婚年龄、以及家族肿瘤史、高血压和烟、酒嗜好等因素也进行了调查分析,未能证实这些因素与卵巢癌发病有关。
英文摘要:
      A Case-control Study was undertaken to explore the high-risk factors of epithelial Carcinoma of the ovary (ovarian carcinoma). Data were collected from 62 females with ovarian carcinoma and 124 age-matched controls on such items as menarche history, fertility, virus infection, living habits, etc. Three factors appeared to be significantly related to the development of ovarian carcinoma. These are irregular menstruation, parity (nulliparity or low parity), and mumps virus infection; low parity in particular had the highest relative risk (χ2 test for trend, P<0.05). It suggests that pregnancy may be a protective factor for ovarian carcinoma. No significant differences were noted between cases and controls as to such factors as menarche, menopause, age of first birth or mrriage, family history of tumor, hypertension, and living habits.
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