| 殷书荣,蒋豫图,巩志立,蒋存梅,王琪.母亲乙型肝炎病毒感染状态对婴儿接种乙型肝炎疫苗后免疫应答的影响[J].中华流行病学杂志,1989,10(4):198-202 |
| 母亲乙型肝炎病毒感染状态对婴儿接种乙型肝炎疫苗后免疫应答的影响 |
| Immune Response to Hepatitis B Vaccine in Neonates Born to Mothers with Various Infection Status of Hepatitis B Virus |
| 收稿日期: 出版日期:2021-06-01 |
| DOI： |
| 中文关键词: 乙型肝炎疫苗 乙型肝炎表面抗体 乙型肝炎母婴传播 |
| 英文关键词: Hepatitis B vaccine Anti-HBs Maternal-infant transmission of HBV |
| 基金项目: |
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| 摘要点击次数: 1736 |
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| 中文摘要: |
| 161例婴儿接种乙型肝炎(简称乙肝)疫苗后免疫应答良好。接种20μg疫苗的婴儿抗-HBs阳转率为100%,几何平均滴度为1:448.9;接种10μg疫苗的婴儿抗-HBs阳转率为97.3%,滴度为1:217.8。母亲的HBV感染状态与婴儿对乙型肝炎疫苗的免疫应答有密切关系。母亲单独抗-HBs阳性的婴儿,接种乙型肝炎疫苗后的抗-HBs应答最佳(阳转率为100.0%,几何平均滴度1:670.4),依次为母亲HBV感染标记全阴性的婴儿(100.0%,1:376.4)。母亲抗-HBs和抗-HBc共阳性的婴儿(100.0%,1:218.2);而母亲为HBsAg阳性或单独抗-HBc阳性的婴儿的抗-HBs应答较差(75.0%,1:40.3;或100.0%,1:28.5)。本次研究提示机体的遗传特征以及母体HBV传染性强弱对婴儿接种乙型肝炎疫苗后的免疫应答起决定作用。 |
| 英文摘要: |
| Hepatitis B (HB) vaccine induced high levels of antibodies against HB surface antigen (HBsAg) in 161 neonates.Seven months after the first vaccination,100.0 percent of the neonates who received 20μg vaccine or 97.3 percent of those who got 10μg vaccine developed anti-HBs with GMT of 1:448.9 or 1:217.8, respectively.HBV infection status of mothers were closely related to immune responses to hepatitis B vaccine in their babies.The babies born to mothers who were only anti-HBs positive had the strongest immune response, and their seroconversion rate and GMT of anti-HBs were 100.0% and 1:670.4, respectively. The weakest response was observed in babies born to mothers who were HBsAg carriers (75.0%, 1:40.3), or only anti-HBc positive (100.0%, 1:28.5), especially those who were positive for HBsAg and HBeAg; The intermediate response was found in babies born to mothers who were negative for all the HBV markers (100.0%, 1:376.4), or positive for both anti-HBs and anti-HBc (100.0%, 1:218.2). It is postulated that some genetic factor and the existence of HBV in mothers may play important roles in immune response to HB vaccine in their babies. |
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