| 卢桥生,骆抗先,朱华强,付超,王安位,林汝洪,杨守昌,潘南胜,梁炽森,陈家芳,严燕.某监狱乙型肝炎病毒感染的前瞻性血清流行病学调查[J].中华流行病学杂志,1990,11(5):267-270 |
| 某监狱乙型肝炎病毒感染的前瞻性血清流行病学调查 |
| A Prospective Serological Epidemiological Investigation of Hepatitis B Virus Infection in a Prison |
| 收稿日期:1989-02-16 出版日期:2021-06-07 |
| DOI： |
| 中文关键词: 乙型肝炎病毒抗原 血清转换 慢性无症状携带 感染率 |
| 英文关键词: Hepatitis B Virus antigen Seroconversion Chronic asymptomatic carrier Infection rate |
| 基金项目:国家自然科学基金资助项目 |
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| 中文摘要: |
| 男性青壮年犯人2443人,随访观察12~36(23.7±11.4)个月,每年检测血清乙型肝炎病毒标志物。初次检测只85人8检出率25.1%(614/2443),其中一过性携带14.7%,慢性携带85.3%,后者HBsAg年阴转率为1.4%.该人群中抗-HBs检出率46.3%(1 130/2 443),年消失率6.0%,提示经常暴露于HBV而抗体应答持续存在。HBeAg年阴转率22.3%,HBeAg阳转率7.9%,提示感染状态的持续性和波动性。人群感染率(HBsAg、抗-HBs、抗-HBc-项或一项以上阳性)为81.1%(1 981/2 443),而初检血清标志物阴性的易感者,年感染率22.3%。 |
| 英文摘要: |
| 2 443 male prisoners were under investigation, most of them were youth, and followed up for 12~36(mean 23.7±11.4) months. Sera HBV markers were detected every year. The positive rate of HBsAg was 25.1%,in which transient HBV carriers were 14.79% and chronic asymptomatic HBV carriers(AsC) were 85.3%. Seroconversion rate of HBsAg in AsC was 1.49% per year.The positive rate of anti-HBs was 46.3%, anti-HBs diminished in 6.0% per year. It was suggested that the antibody response to frequent exposure to HBV persisted for a long time. HBeAg seroconversion was 22.3% per year, and its reoccurrence was 7.9% per year, indicating the fluctuation and stability of infection status. The prevalence rate of HBV infection(with one or more than one of HBsAg, anti-HBs or anti-HBc) was 81.1%. Incidence of HBV infection among those susceptible persons found at first investigation was 22.3% per year. |
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