文章摘要
陈建国,陆建华,龚惠民,柳标.肝癌家庭HBV感染的病例-对照研究 条件Logistic回归模型的应用[J].中华流行病学杂志,1991,12(4):208-212
肝癌家庭HBV感染的病例-对照研究 条件Logistic回归模型的应用
A Case-Control Study on HBV Infection in Families of Hepatocellular Carcinoma Application of Conditional Logistic Regression Model
收稿日期:  出版日期:2021-06-07
DOI:
中文关键词: 肝癌;HBV;病例-对照研究;Logistic模型
英文关键词: Hepatocellular carcinoma;HBV;Case-control study;Logistic regression model
基金项目:
作者单位
陈建国 江苏省启东肝癌防治研究所 226200 
陆建华 江苏省启东肝癌防治研究所 226200 
龚惠民 江苏省启东肝癌防治研究所 226200 
柳标 江苏省启东肝癌防治研究所 226200 
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中文摘要:
      用病例-对照研究的方法,结合条件Logistic回归模型,分析了肝癌家庭的乙型肝炎病毒五项感染标记(HBVM)。肝癌的HBV感染率为88.89%,对照为55.56%,差异有极显著性(P<0.01)。在条件Logistic回归方程中贡献最大的为指示者的HBsAg与抗-HBc的交互影响项以及指示者同胞的HBVM。两组配偶之间的HBVM及单项标记的差异均无显著性(P>0.05)。研究表明肝癌家族内有HBV感染的聚集性。
英文摘要:
      To assess the risk of HBV infection in families of hepatocellular carcinoma (HCC), methods of case-control study and conditional logistic regression model were applied. The total infection rate of HBV was 88.89% in cases and 55.56% in controls, showing a statistically significant difference (P<0.01). Analysis of logistic model showed that the variable interaction of HBsAg and anti-HBc in pointer group and the variable five-HBYmarker in siblings group were the most important risk factors in these families. However, no significant difference was found in each marker of HBV between two spouse-groups (P> 0.05). This study indicates a familial clustering of HBV infection in HCC families.
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