| 陈建国,陆建华,龚惠民,柳标.肝癌家庭HBV感染的病例-对照研究 条件Logistic回归模型的应用[J].中华流行病学杂志,1991,12(4):208-212 |
| 肝癌家庭HBV感染的病例-对照研究 条件Logistic回归模型的应用 |
| A Case-Control Study on HBV Infection in Families of Hepatocellular Carcinoma Application of Conditional Logistic Regression Model |
| 收稿日期: 出版日期:2021-06-07 |
| DOI： |
| 中文关键词: 肝癌 HBV 病例-对照研究 Logistic模型 |
| 英文关键词: Hepatocellular carcinoma HBV Case-control study Logistic regression model |
| 基金项目: |
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| 中文摘要: |
| 用病例-对照研究的方法,结合条件Logistic回归模型,分析了肝癌家庭的乙型肝炎病毒五项感染标记(HBVM)。肝癌的HBV感染率为88.89%,对照为55.56%,差异有极显著性(P<0.01)。在条件Logistic回归方程中贡献最大的为指示者的HBsAg与抗-HBc的交互影响项以及指示者同胞的HBVM。两组配偶之间的HBVM及单项标记的差异均无显著性(P>0.05)。研究表明肝癌家族内有HBV感染的聚集性。 |
| 英文摘要: |
| To assess the risk of HBV infection in families of hepatocellular carcinoma (HCC), methods of case-control study and conditional logistic regression model were applied. The total infection rate of HBV was 88.89% in cases and 55.56% in controls, showing a statistically significant difference (P<0.01). Analysis of logistic model showed that the variable interaction of HBsAg and anti-HBc in pointer group and the variable five-HBYmarker in siblings group were the most important risk factors in these families. However, no significant difference was found in each marker of HBV between two spouse-groups (P> 0.05). This study indicates a familial clustering of HBV infection in HCC families. |
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