| 唐时幸,于光烈,程绍尧.乙肝病毒宫内感染机制及影响因素的研究[J].中华流行病学杂志,1991,12(6):325-326 |
| 乙肝病毒宫内感染机制及影响因素的研究 |
| Study on the Mechanisms and Influential Factors of Intrauterine Infection of Hepatitis B Virus |
| 收稿日期:1989-11-02 出版日期:2021-06-09 |
| DOI： |
| 中文关键词: HBV 抗-HBc 胎盘 |
| 英文关键词: HBV Anti-HBc Placenta |
| 基金项目: |
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| 中文摘要: |
| 从2例宫内感染胎儿胎盘组织检测到HBV DNA,提示HBV可通过胎盘屏障感染胎儿,或者先感染胎盘组织并在其中复制,再感染胎儿。研究表明因胎盘破裂,母血混入而感染胎儿不是宫内感染的主要原因。母亲HBeAg阳性,尤其是HBV DNA阳性,其胎儿宫内感染的机率较大,但来自母体的抗-HBc没有抑制HBV复制和表达的作用。 |
| 英文摘要: |
| Molecular hybridization methods were used to study the intrauterine HBV infection in induced abortions. HBV-DNA was detected not only in fetal liver, but also in spleen, Pancreas, kidney and placenta. The results suggested that HBV might probably pass through placental barrier or infect the placenta leading to the intrauterine HBV infection. Even a possible vertical transmission of HBV via the germ line might exist. However, it might not be the main way by which the maternal blood entered fetal circulation through placental leakage leading to intrauterine infection of HBV. In maternal blood, HBeAg positivity, especially also positive for HBV-DNA was important for intrauterine infection. But maternal anti-HBc antibody may not be able to suppress HBV antigens expression and HBV replication in fetal tissue. |
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