文章摘要
张超,王润田,王天根.北京市250例大肠癌的病例对照研究[J].中华流行病学杂志,1992,13(6):321-324
北京市250例大肠癌的病例对照研究
A case-control Study of Colorectal Cancer in Beijing
收稿日期:1991-06-26  出版日期:2021-06-05
DOI:
中文关键词: 大肠癌;危险因素
英文关键词: Colorectal cancer;Risk factors;Case-control study
基金项目:
作者单位
张超 北京医科大学流行病学教研室 100083 
王润田 北京医科大学流行病学教研室 100083 
王天根 北京医科大学流行病学教研室 100083 
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中文摘要:
      本文对北京市四个城区1988年1月1日至1989年6月30日诊断的大肠癌进行了1:2配对的病例对照研究。对研究因素进行了单因素及多因素的统计分析。结果表明:与大肠癌发生有直接关联的因素有肉、食用油的多量摄入,长期从事低体力活动的工作等;多食蔬菜及经常生食蔬菜对大肠癌的发生具有保护作用。研究结果支持了大肠癌发生的脂肪胆汁酸假说及纤维缺乏假说。
英文摘要:
      A case-control study was conducted among 250 persons suffering from cancer of the colon and rectum (CRC) in the urban area of Beijing from Jan 1, 1988-June 30, 1989 to explore the risk factors for CRC.500 neighbour residents were matched as Control.
The chi-square test and Conditional Logistic Regression analysis show that high consumption of meat, oil, low occupational physical activity and psychological stress were risk factors of CRC.A trend of increased odds ratio (OR) of CRC with high meat intake and a trend of decreased OR with increased occupational physical activity were found. The high consumption of vegetables and the habit of eating uncooked fresh vegetables showed a protective effect on CRC.
The results of the study support the CRC etiological hypotheses of "fat-bile acid action" and "deficiency of dietary fibres".
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