各型病毒性肝炎、肝癌抗—HCV检测及HCV感染与输血的关系

赵龙凤; 郎丽娟; 张玲荣; 项淑娟

文章摘要

赵龙凤,郎丽娟,张玲荣,项淑娟.各型病毒性肝炎、肝癌抗—HCV检测及HCV感染与输血的关系[J].中华流行病学杂志,1994,15(6):354-356

各型病毒性肝炎、肝癌抗—HCV检测及HCV感染与输血的关系

The Anti-HCV Assay in Viral Hepatitis and Hepatoma and the Relationship between HCV Infection and Blood Transfusion

收稿日期:1993-06-03 出版日期:2021-05-29

DOI：

中文关键词: 病毒性肝炎抗—HCV

英文关键词: Viral hepatitis Anti-HCV

基金项目:

作者	单位
赵龙凤	山西医学院第一附属医院 030001 太原市
郎丽娟	山西医学院第一附属医院 030001 太原市
张玲荣	山西医学院第一附属医院 030001 太原市
项淑娟	山西医学院第一附属医院 030001 太原市

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中文摘要:

本文对各型病毒性肝炎、肝癌200例进行血清抗—HCV检测,阳性率为20.5%,以重型肝炎和肝硬化检出率为高,分别为42.86%、46.15%,二者与其他型肝炎相比,有显著性差异(P<0.05)。输血后肝炎抗-HCV阳性率为67.5%,健康献血员抗HCV阳性率为20.47%,而输血后乙型肝炎仅占2.5%。说明输血是造成丙型肝炎传播的重要途径,因此,对献血员应进行严格筛选。
观察表明,HBV与HCV双重感染,可能是形成慢性肝炎,肝硬化以及促使肝炎向重型发展的重要原因之一。抗—HCV阳性的慢性肝炎,血清ALT50%在正常范围内,余者仅轻度升高,说明HCV感染所致的肝损伤可能是一个较慢的过程

英文摘要:

Two hundred cases of various kinds of viral hepatitis and hepatocellular carcinoma were tested for serum anti-HCV. The positive rates of anti-HCV in patients with severe hepatitis and patients with cirrhosis were 42.86% and 46.15%, respectively. They were significantly higher than those in patients with other kinds of hepatitis (P<0.05).
The positive rate of anti-HCV was 67.5% in patients with posttransfusion hepatitis, 20.47% in healthy blood donors. In posttransfusion hepatitis B it was only 2.5%. Our results demonstrated that blood transfusion played an important role in transmitting HCV.
Our findings also indicated that dual infection of HBV and HCV was important in the course of chronic hepatitis, cirrhosis and severe hepatitis. 50% of the anti-HCV positive patients with chronic hepatitis had slightly elevated serum alanine aminotransferase level. This showed that liver demage caused by HCV may be a chronic course.

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