| 刘白玉,冯增欣,徐爱强,李世瑞,王常银,秦玲,臧大学.4~7月龄婴儿麻疹胎传抗体及初次接种麻疹疫苗免疫应答的研究[J].中华流行病学杂志,1995,16(5):263-265 |
| 4~7月龄婴儿麻疹胎传抗体及初次接种麻疹疫苗免疫应答的研究 |
| A Study on the Level of Antibody against Measles through Maternal-fetal Transfer and the Immuno-Response to Measles Vaccine among 4 to 7 Month olds |
| 收稿日期:1994-12-22 出版日期:2021-05-24 |
| DOI： |
| 中文关键词: 麻疹疫苗 免疫应答 |
| 英文关键词: Measles vaccine Immune response |
| 基金项目: |
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| 摘要点击次数: 944 |
| 全文下载次数: 219 |
| 中文摘要: |
| 笔者对143名4~7月龄婴儿麻疹胎传抗体及其对麻疹疫苗的免疫应答情况进行了研究,结果表明:4~7月龄婴儿麻疹胎传抗体的阴性率为75.00%~94.87%,且6~7月龄婴儿较4~5月龄婴儿的阴性率更低(χ2=5.11,P<0.05);而4~7月龄婴儿初免麻疹疫苗后,其免疫成功率为84.38%~100.00%,6~7月龄婴儿的免疫成功率显著高于4~5月龄的婴儿(χ2=5.37,P<0.05),GMT在各月龄组婴儿中的差异亦存在显著性意义(F=5.40,df=3,P<0.01)。另外,初免麻疹疫苗前麻疹抗体的滴度对免疫应答结果有明显的影响。综合以上结果,笔者认为要减少1岁内婴儿(尤其是9月龄以下婴儿)麻疹的发病,应将麻疹疫苗的初免时间提月龄。 |
| 英文摘要: |
| A total number of 143 infants at the age of 4 to 7 months from Yantai city-Shandong was selected for the study of antibody level against measles by maternal-fetal transfer and immuno-res-ponse to measles vaccine in October of 1993. The results showed that the negative rates of maternal-fetal antibody among infants of 4, 5, 6 and 7 month olds were 75.00%, 81.25%, 94.87%and 90.91%, respectively. The positive rates and geometric mean titers (GMTs) for immuno-response to measles vaccine were 92.86%, 84.38%, 97.44%, 100.00% and 55.17, 42.41, 69.95, 71.46, respectively. There was significant lower immune response to measles vaccine in infants who had high titer (>1:2) than those who had low titer (≤ 1:2) of maternal-fetal antibody (χ2=88.38, P<0.001). In order to decrease the number of measles cases under 1 year old (especially under 9 month-old), the author suggested that the primary immunization for measles vaccine should be started at 6 month olds. |
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