文章摘要
孔健,郭绍红,迮文远.空斑减少中和试验与血凝抑制试验测定血清抗麻疹病毒抗体的比较[J].中华流行病学杂志,1996,17(2):105-107
空斑减少中和试验与血凝抑制试验测定血清抗麻疹病毒抗体的比较
Comparison between The Plaque Reduction Neutralization Test and the Hemagglutination Inhibition Test in Determination of Human Anti-measles Antibodies
收稿日期:1995-11-13  出版日期:2021-05-13
DOI:
中文关键词: 空斑减少中和试验;血凝抑制试验;麻疹疫苗
英文关键词: Plaque reduction neutralization test;Hemagglutination inhibition test;Measles vaccine
基金项目:
作者单位
孔健 卫生部北京生物制品研究所 100024 
郭绍红 卫生部北京生物制品研究所 100024 
迮文远 卫生部北京生物制品研究所 100024 
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中文摘要:
      为了对比空斑减少中和试验与血凝抑制试验在评价人血清抗麻疹病毒抗体测定结果时的异同,对328名3~6月龄儿童接种沪191麻疹疫苗前后的血清样本用以上两种方法进行了测定。结果表明,在测定免前血清抗麻疹病毒抗体时,空斑减少中和试验比血凝抑制试验灵敏,在测定免后血清抗麻疹病毒抗体时,两种方法测定结果无显著性差异。空斑减少中和试验能测出婴儿血清中存在的极少量的母传抗体,在考核母传抗体对麻疹疫苗免疫效果的影响时,应考虑选用。
英文摘要:
      In order to evaluate the difference between plaque reduction neutralization test(PNt) and hemagglutination inhibition (HI)test on human anti-measles antibodies, pre-and postimmunization sera collected from 328 infants aged 3-6 months who were immunized with Shanghai 191 measles vaccine, were detected by both methods. The results demonstrated that PNt was more sensitive than HI when they were used to measure the pre-immunization sera. No significant difference was found between these two methods when they were used to measure the post-immunization sera. PNt can be used to test low level maternal anti-measles antibodies in infants, especially for estimating the effect of maternal anti-measles antibodies on the immunogenicity of measles vaccine.
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