文章摘要
吕嘉春,施侣元.儿童白血病的病例对照研究[J].中华流行病学杂志,1996,17(4):229-232
儿童白血病的病例对照研究
A Case-Control Study of Childhood Leukemia
收稿日期:1995-11-01  出版日期:2021-05-13
DOI:
中文关键词: 白血病  儿童病例对照研究
英文关键词: Childhood leukemia  Case-control study
基金项目:
作者单位
吕嘉春 广州医学院化学致癌研究所 广州 510182 
施侣元 同济医科大学流行病学教研室 
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中文摘要:
      为了探讨儿童白血病的主要病因,进行1:1配对病例对照研究,结果发现5个危险因素:住家附近有三废污染OR(95% CI)为2.84(1.14~7.10),极低频电磁场暴露OR为2.01(1.18~3.42),儿童X线暴露OR为4.53(1.68~12.21),儿童服用氯霉素OR为3.60(1.62~8.01),服解热镇痛类药物OR为1.93(1.09~3.42);1个保护因素:母亲孕期经常食用鱼、肉类食品OR为0.33(0.18~0.59)。总人群归因危险度表明人群中91%的病例可归因于上述危险因素;X线暴露与氯霉素对儿童白血病的发生有正的交互作用,其相对超额危险度为3.04。
英文摘要:
      A 1:1 matched case-control study was conducted to investigate the etiological factors of childhood leukemia. It was found that there were five risk factors:(1) children living in the environmencal pollution area, OR (95% CI)=2.84 (1.14-7.10); (2) exposure to extreme low frequency electronmagnetic field (ELF), OR (95% CI)=2.01 (1.18-3.12); (3) history of postnatal X-ray exposure, OR (95% CI)=4.53 (1.68-12.21); (4) history of taking chloramphenicol, OR (95% CI)=3.60 (1.62-8.01); (5) history of taking antipyretic or analgesic drugs, OR (95% CI)=1.93(1.09-3.42). A protective factor was also discovered. Mothers often eating fish, pork and other meat foods, OR (95% CI)=0.33 (0.18-0.59). The analysis of the population attributable risk showed that 91% of the childhood leukemia cases might attribute to these five risk factors. The interaction among these etiological factors was estimated. Results showed that there was a positive interaction between the X-ray exposure and chloramphenicol on additive model, the relative excess risk due to interaction (RERI) of childhood leukemia was 3.04.
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