文章摘要
熊小卫,刁连东,严旭玲,姜维平,冯捌晓,黄和兴.不同年龄人群对风疹疫苗的免疫应答研究[J].中华流行病学杂志,1997,18(4):227-229
不同年龄人群对风疹疫苗的免疫应答研究
Immune Response of Rubella Vaccine in the Populations with Different Age Groups
收稿日期:1996-11-26  出版日期:2021-06-09
DOI:
中文关键词: 风疹疫苗;免疫应答
英文关键词: Rubella vaccine;Immune response
基金项目:
作者单位
熊小卫 江苏省卫生防疫站 南京 210009 
刁连东 江苏省卫生防疫站 南京 210009 
严旭玲 江苏省卫生防疫站 南京 210009 
姜维平 常州市卫生防疫站 
冯捌晓 金坛市卫生防疫站 
黄和兴 溧阳市卫生防疫站 
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中文摘要:
      作者报告了江苏省在风疹疫苗使用前人群的自然免疫状况,4岁以下年龄组血凝抑制(HI)抗体阳性率在25%以下,随着年龄的增长,自然免疫水平增高,13~25岁人群阳性率约在80%左右。接种风疹疫苗1月后,抗体100%阳转,GMT从免前的13.33上升至243.16,说明国产BRDⅡ株风疹减毒活疫苗具有良好的免疫原性。对于免前阳性人群,风疹疫苗接种后抗体亦有显著性上升。
英文摘要:
      The natural immunity status in different age groups was investigated. The positive rate of HI antibody under the age of 4 was less than 25%. The natural immunity level increased gradually with age and the positive rate of the antibody reached 80% among the group aged 13-25.Rate of seroconversion was 100% in any age group one month after immunization,and GMT rose from 13.33 to 243.16. It was suggested that immunogenicity of domestic attenuated live rubella vaccine BRD Ⅱ was satisfactory. For the population with positive antibody before immunization,the total GMT rose from 189.59 to 259.00 after vaccination and the difference between immunization before and after was highly significant. According to the above result,we suggested that the vaccination strategy for rubella among young children and women of child bearing age should be implemented.
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