| 车莉,卢竞,鲁杰,赵小元,刘小燕.肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测[J].中华流行病学杂志,1999,20(1):50-52 |
| 肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测 |
| Measurement of serum tumor necrosis factor-αand interleukin-8 in children with low respiratorytract infection (LRTI) caused by Mycoplasma pneumonia |
| 收稿日期:1998-09-29 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 支原体.肺炎 肿瘤坏死因子 白细胞介素-8 |
| 英文关键词: Mycoplasa pneumonia Tumor necrosis factor Interleukin-8 |
| 基金项目: |
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| 中文摘要: |
| 目的 探索肺炎支原体所致下呼吸道感染的免疫学发病机制。方法 采用顺序饱和液相竞争放射免疫分析法及夹心酶免疫放射分析法对３０ 例肺炎支原体所致下呼吸道感染患儿血清进行了肿瘤坏死因子（ＴＮＦ）-α和白细胞介素-８（ Ｉ Ｌ-８） 的检测。结果 肺炎支原体所致下呼吸道感染患儿血清中 Ｔ Ｎ Ｆ-α及 Ｉ Ｌ-８ 水平均明显高于健康儿童； Ｔ Ｎ Ｆ-α和 Ｉ Ｌ-８ 升高呈正相关。结论 Ｔ Ｎ Ｆ-α在肺炎支原体所致下呼吸道感染中起着重要作用，也是 Ｉ Ｌ-８ 升高的重要促进因子。 |
| 英文摘要: |
| Objective To investigate the immunopathological mechanism of LRTI caused by Mycoplasma pneumonia.Methods Serum tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) from 30 patients with LRTI caused by Mycoplasma pneumonia, were measured with sequence saturated solution competitive radioimmunoassay and sandwich ELISA.Results The level of serum TNF-α and IL-8 of patients suffering from LRTI caused by Mycoplasma pneumonia were magnificently higher than that of healthy children. Meanwhile, a positive relationship between serum TNF-α and IL-8 was noticed.Conclusion TNF-αplays an important role in LRTI caused by Mycoplasma pneumonia, and serves the key factor to the elevation of IL-8. |
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