文章摘要
李忠佑,高长明,丁建华,王建东,王亚平,胡旭,刘体康,ToshiroTakezaki,KazuoTajima.[J].中华流行病学杂志,1999,20(2):88-90
Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds
收稿日期:1998-07-29  出版日期:2014-09-16
DOI:
中文关键词: 幽门螺杆菌;上消化道癌;亲属对照;流行病学
英文关键词: Helicobacter pylori;Upper-digestive tract cancer;Kindreds;Epidemiology
基金项目:日本文部省国际学术研究癌症特别调查研究经费资助
作者单位
李忠佑 江苏省肿瘤防治研究所, 南京 210009 
高长明 江苏省肿瘤防治研究所, 南京 210009 
丁建华 江苏省肿瘤防治研究所, 南京 210009 
王建东 江苏省肿瘤防治研究所, 南京 210009 
王亚平 江苏省肿瘤防治研究所, 南京 210009 
胡旭 淮安市肿瘤防治办公室 
刘体康 邳州市卫生局 
ToshiroTakezaki 日本国爱知县癌中心研究所疫学部 
KazuoTajima 日本国爱知县癌中心研究所疫学部 
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中文摘要:
      目的调查幽门螺杆菌(Hp)感染与上消化道癌危险性的关系。方法在江苏省淮安市和邳州市,应用HpIgG定量酶联免疫(ELISA)检测试剂盒,随机检测312例上消化道癌及其健康一级亲属对照人群外周血中抗HpIgG.结果①胃癌患者中HpIgG抗体水平(阳性率50.0%)高于贲门癌患者和食管癌患者(P>0.05,χ2检验);贲门癌患者与食管癌患者之间,以上三类癌症病例与其自身亲属对照之间,差异亦不明显;②胃癌组病例与亲属同时感染Hp的阳性率(27.1%)显着高于贲门癌组和食管癌组(P<0.05),后两组之间无明显差异。结论Hp感染在胃癌家族中存在明显家庭聚集现象,Hp感染与胃癌危险性的关系有待进一步观察。
英文摘要:
      ObjectiveIn order to analyse the association between Hp infection and the risk of upper-digestive tract cancer.MethodsIn Huaian and Pizou cities,Jiangsu province,Hp IgG quantitative-enzyme-immunoassay methods was used to identify IgG to H.pylori in the serum of 312 cases of upper-digestive tract cancer patients and their kindreds.Results⑴The level of IgG to H.pylori and the IgG positive rate (50.0%)in gastric cancer patients were both higher than that of cardia and esophageal cancer patients (P>0.05,χ2test)but no significant differences w ere observed between cardia and esophageal cancer patients,3 typies of cancer patients and their kindreds;⑵the overall positive rates of both patients and kindreds in gastric cancer families (27.1%)were significantly higher than that of cardia or esophageal cancer families (P<0.05)but no significant differences were observed between cardia and esophageal groups.ConclusionH .pylori infection w as not thought to be correlated with the development of gastric cancer,although higher clustering of Hp infection in families afflicted with gastric cancer was noticed.
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