文章摘要
陈宪锐,玄梅香,吴多文,尹燕明,张玉江,周玉霞,魏佑农,付春生.乙型和丙型肝炎病毒重叠感染的研究[J].中华流行病学杂志,1999,20(3):141-143
乙型和丙型肝炎病毒重叠感染的研究
Study of superinf ection of HBV and HCV
收稿日期:1998-11-10  出版日期:2014-09-16
DOI:
中文关键词: 乙型肝炎病毒;丙型肝炎病毒;丙型肝炎病毒抗体
英文关键词: HBV;HCV;A nti-HCV
基金项目:
作者单位
陈宪锐 泰山医学院, 泰安 2710002 
玄梅香 山东省泰安市卫生防疫站 
吴多文 泰山医学院, 泰安 2710002 
尹燕明 泰山医学院, 泰安 2710002 
张玉江 泰山医学院, 泰安 2710002 
周玉霞 泰山医学院, 泰安 2710002 
魏佑农 山东新汶矿务局中心医院 
付春生 山东聊城地区人民医院 
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中文摘要:
      目的为了解乙型肝炎患者重叠感染丙型肝炎病毒(HCV)的状况,并探讨乙型肝炎病毒(HBV)、HCV重叠感染时HCV对HBV复制的影响。方法应用ELISA法对712例乙型肝炎患者进行了血清抗-HCV检测和乙型肝炎病毒标志检测。结果712例乙型肝炎患者血清抗-HCV阳性率为14.47%,其中重型肝炎患者血清抗-HCV阳性率最高(48.98%),急性肝炎患者最低(3.25%)。在不同临床类型的乙型肝炎患者之间,血清抗-HCV阳性率存在显著性差异(P<0.001),显示病情越重,病程越长,血清抗-HCV阳性率越高;在HBV和HCV重叠感染的患者中,血清HBsAg、HBeAg和抗-HBcIgM阳性率低于乙型肝炎患者(P<0.001,P<0.001和P<0.05),而血清抗-HBe阳性率高于乙型肝炎患者(P<0.01),均有显著的统计学意义。结论乙型肝炎患者重叠感染HCV与病情加重和慢性化的形成有关,并使HBV的复制受到抑制。
英文摘要:
      Objectives T o understand the situation in hepatitis B pat ients coinciding w ith HCV and to ex plor e its influence on HCV on the replication of HBV . Methods U sing ELI SA, 712 hepatit is B patients w er e tested for serum anti-HCV and mar kers of HBV. Results Of the 712 patients, anti-HCV posit ive rate w as 14. 47% w ith the hig hest 48. 98% in patients wit h severe hepatitis and the lowest 3. 25% in patients w ith acute hepatitis. M arkedly different anti-HCV positiv e rates ( P <0. 001) in patients of different clinical stag es w ere discover ed. The more severe the case with long er the course, the higher the ant i-HCV positive rates. In patients w ith superinfection of HBV and HCV,serum HBsAg, HBeA g and anti-HBcIgM positive rates were lower than those in patients w ith hepatitisB ( P < 0. 001, P < 0. 001 and P < 0. 05) but the anti -HBe positive rates w er e higher . All the differ ences show ed an obvious statistical significance. Conclusion Hepatitis B coinciding w ith HCV infectio n is r esponsible for the deter ioration of the disease and towards its fo rmat ion of its chronic phase as w ell as for the inhibition of HBV replication.
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