文章摘要
唐根富,李涛,张冬梅,徐爱晖,庞玉瑛.儿童哮喘病遗传流行病学研究[J].中华流行病学杂志,1999,20(3):151-154
儿童哮喘病遗传流行病学研究
A study of genetic epidemiology on child bronchial asthma
收稿日期:1998-08-05  出版日期:2014-09-16
DOI:
中文关键词: 儿童;哮喘;遗传流行病学
英文关键词: Children;Asthma; Genetic epidemiology
基金项目:
作者单位
唐根富 安徽医科大学卫生管理学院社会医学与临床流行病学教研室, 合肥 230032 
李涛 安徽医科大学卫生管理学院社会医学与临床流行病学教研室, 合肥 230032 
张冬梅 安徽医科大学卫生管理学院社会医学与临床流行病学教研室, 合肥 230032 
徐爱晖 安徽医科大学附属医院呼吸科 
庞玉瑛 安徽医科大学附属医院呼吸科 
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中文摘要:
      目的探讨遗传因素在儿童哮喘病发病中的作用。方法用病例对照的研究方法,确定了186例哮喘患儿为先证者,收集了186对核心家系的资料进行了遗传流行病学研究。结果儿童哮喘病具有明显家族聚集性(X2=24.80,P<0.01),先证者Ⅰ、Ⅱ级亲属哮喘病患病率(分别为13.68%和5.30%)明显高于对照组(1.96%)。哮喘病分离比为0.14,95%可信限为0.097~0.18,哮喘病?、ò级亲属遗传度分别为78.18%和55.02%,且女性亲属遗传度(83.64%)明显高于男性(73.48%)。结论哮喘病属多基因遗传方式,遗传因素是儿童哮喘病的主要危险因素,且对女性更明显。
英文摘要:
      ObjectiveTo examine the relationship between child bronchial ast hma and genetic fastor. Methods A case -control study including 372 pedigree w as carried out. Results Child bronchial asthma had obvious familiar cluster ing (X2= 24.8, P< 0.01) . The prev alence rate of the first and the second deg ree relatives of pr oband was sig nifically hig her than that of the controls. The seg regation ration of asthma w as 0.14 ( 95% CL 0. 098~ 0. 18) . The h2of the first and second degree relatives of ast hma were 78.18% and 55.02% , of which 83. 64% fo r female and 73. 48% for male.Conclusion The genetic model of asthma belong ed to polyg enetics. Genetic fastor was a main risk fastor for ast hma, especially for female patients.
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