文章摘要
韩存芝,梁小波,荆洁线,江波,赵先文,郭晋纲,李跃平,白文启.微量元素与直肠癌关系的分析及意义[J].中华流行病学杂志,1999,20(3):166-169
微量元素与直肠癌关系的分析及意义
Study on the association and significance between trace elements and rectal cancer
收稿日期:1999-03-16  出版日期:2014-09-16
DOI:
中文关键词: 直肠癌;微量元素
英文关键词: Rectal cancer;Trace element
基金项目:
作者单位
韩存芝 山西省肿瘤研究所病因室, 太原 030013 
梁小波 山西省肿瘤医院肛肠外科 
荆洁线 山西省肿瘤研究所病因室, 太原 030013 
江波 山西省肿瘤医院肛肠外科 
赵先文 山西省肿瘤研究所病因室, 太原 030013 
郭晋纲 山西省肿瘤研究所病因室, 太原 030013 
李跃平 山西省肿瘤医院肛肠外科 
白文启 山西省肿瘤医院肛肠外科 
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中文摘要:
      目的探讨部分微量元素与直肠癌发病的关系。方法采用原子吸收分光光度计对60例直肠癌患者的癌组织,非病变组织及血清中铜、锌、铁、锰、钙、铬、镉水平及铜/锌比值进行测定,采用t检验和非条件logistic回归多因素分析方法对测定结果进行分析。结果直肠癌患者血清、癌组织中铜、镉水平和铜/锌比值与健康对照组和非病变组织比较明显高;而锌、锰、钙、铬水平则明显低,均差异有显著性(P<0.05、P<0.001)。蕈伞型癌组织中铜水平和铜/锌比值高于溃疡型,而锌低于溃疡型,差异有显著性(均P<0.01)。在癌组织和非病变组织中最终进入方程的元素有锌,与直肠癌的相对危险度(OR)为0.3051,95%可信限CI为0.1549~0.6011。在癌患者和健康人血清的比较中,最终进入方程的元素有铜、锌、锰和钙,与直肠癌OR值(95%CI)分别为29.44(4.1748~207.6228)、0.0960(0.0162~0.5679)、0.0426(0.0028~59.7126)、0.9646(0.9354~0.9947),经X2检验均差异有显著性(P<0.05、P<0.001)。结论结果提示锌、锰、钙可能是直肠癌保护因素,而铜为危险因素。
英文摘要:
      Objective To study the association between the levels of trace elements and cause of rectal cancer. Methods Cancer tissue, normal tissue, serum levels of Zinc、Copper 、Iron、M anganese、Calcium、Chr omium and Cadmium and Cu/ Zn ratio were determined by atomic absor ption spectrophotometry in 60 pat ients w ith r ectal cancer and in 60 healthy subjects. Results The results of single-variabe analysis showed in serum and malig nant tissue of patients with rectal cancer of Copper、Cadmium levels and Cu/ Zn ratio were sig nificantly higher and Zinc、M anganese、Calcium、Chromium were significantly lower than normal tissue and serum of healthy subjects ( P < 0. 05、P < 0. 001) . The results also showed that Copper level and Cu/ Zn ratio were significantly higher and Zinc level was significantly lower in fung at ing form than ulceration for m cancer tissue( both P v alues < 0. 01) . Multivar iable logistic regression analysis showed that the Odd Ratio ( OR) and 95% Confidence Iimits ( CI) of Copper、Zinc、M anganese and Calcium in serum were 29. 44( 4. 1748-207. 6228) 、0. 0960( 0. 0162-0. 5679) 、0. 0426 ( 0. 0028 -59. 7126 ) and 0. 9646 ( 0. 9354 -0. 9947) r espectiv ely. The OR and 95% CI of Zinc in tissue were 0. 3051 and 0. 1549-0. 6211 respectively. Conclusions Our results indicated that Copper mig ht serve as a risk factor while Zinc、Calcium and M ang anese w ere protective factors to the cause of rectal cancer.
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