文章摘要
潘国宗,鲁素彩,柯美云,韩少梅,郭慧平,方秀才.北京地区肠易激综合征的流行病学研究:一个整群、分层、随机的调查[J].中华流行病学杂志,2000,21(1):26-29
北京地区肠易激综合征的流行病学研究:一个整群、分层、随机的调查
An epidemiologic study of irritable bowel syndrome in Beijing — A stratified randomized study by clustering sampling
收稿日期:1999-03-22  出版日期:2014-10-17
DOI:
中文关键词: 肠易激综合征  流行病学
英文关键词: Irritable bowel syndrome (IBS)  Epidemiology
基金项目:杨森科学委员会中国分会资金项目
作者单位
潘国宗 中国医学科学院
中国协和医科大学协和医院消化科 100730 
鲁素彩 中国医学科学院
中国协和医科大学协和医院消化科 100730 
柯美云 中国医学科学院
中国协和医科大学协和医院消化科 100730 
韩少梅 协和医科大学统计教研室 
郭慧平 河北职工医学院附属医院 
方秀才 河南医科大学第一附属医院 
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中文摘要:
      目的 对北京市肠易激综合征(IBS)的患病率及危险因素进行研究。方法 用整群、分层、单纯随机抽样方法,对北京市常住人口中18~70岁的2486人进行问卷调查作为初筛,了解按Manning标准加以补充(含便秘)及按罗马标准判断的有症状人群的检出率,再对筛出有症状的部分人在医院进行以排除结肠器质性疾病为目的的精查,根据精查的正确率对普查结果校正后估算出点患病率。对发病有关的危险因素作单因素和多因素分析,并对部分患者作明尼苏达多相个性测查。结果 推测北京市有症状符合Manning标准的IBS患病率为7.26%,符合罗马标准的患病率为0.82%,分层研究表明患病率在城区(10.50%)和郊区(6.14%)差异有显著性(P<0.001),18~40岁为最常见的患病年龄段(51.6%),男女比例接近。经多因素回归分析,痢疾、受凉和凉食为最具可能性的危险因素,其OR值分别为3.0、1.55及1.24,且IBS有心理异常倾向者的比例较高。结论 IBS是北京地区的常见病、多发病;痢疾、受凉和凉食等可能是诱发的危险因素,应积极予以控制
英文摘要:
      Objective To explore the prevalence of irritable bowel syndrome (IBS) and its risk factors in Beijing. Methods Phase I : a screening program for IBS was carried out in Beijing area according to symptoms using both Manning (modified including constipation) and Rome criteria. Random clustered sampling involving 2 486 subjects of the inhabitants was carried out under stratification of city, suburban and rural areas. Sample size of each studied area was in proportion to the population of the area. The range of age was 18-70. All subjects studied were requested to fill in a questionnaire assisted by trained doctors or medical students during the visit to their families. Phase II: a small number of patients who fulfilled the Manning criteria were further selected to undergo detail clinical examination in the hospital including laboratory examination, abdominal ultrasonography, colonoscopy or/and barium enema to exclude organic disease of the colon. Prevalence of IBS of the population was then adjusted by the rate of correct diagnosis during phase II study. Minnesota Multi-Personality Indices was used in some cases. Potential risk factors were explored by comparing frequencies among IBS group and non-IBS group using χ 2 and logistic analysis of multifactors. Results The adjusted point prevalence of IBS in Beijing according to Manning criteria was 7.26 %, in contrast to Rome criteria- 0.82 %. Higher prevalence rate of IBS in the city ( 10.50 %) than in rural areas ( 6.14 %) ( P 0.001 ) was noticed. Male to female ratio was 1: 1.15 with majority of IBS fell in age 18-40 ( 51.6 %), and among intellectuals. Our study indicated that history of dysentery ( OR = 3.00 ), exposure to coldness ( OR = 1.55 ), ingestion of cold food and raw materials ( OR = 1.24 ) might serve as the most important risk factors ( P 0.001 ). Patients with IBS seemed to have a higher tendency of abnormal personalities. Conclusion IBS is a common disorder in Beijing which deserves greater care.
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