| 郑锡文,王哲,徐杰,黄石,王春俭,李自钊,王岚,张桂云,高明,李宏,曲书泉,崔卫国,李晓光,魏卫.中国某县有偿献血员艾滋病病毒感染流行病学研究[J].中华流行病学杂志,2000,21(4):253-255 |
| 中国某县有偿献血员艾滋病病毒感染流行病学研究 |
| The epidemiological study of HIV infection among paid blood donors in one county of China |
| 收稿日期:2000-04-28 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 艾滋病病毒 有偿献血 定群研究 |
| 英文关键词: HIV Paid blood donor Cohort study |
| 基金项目: |
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| 中文摘要: |
| 目的 了解中国有偿献血员HIV感染率及其流行因素。方法 对中国中部某县两个村18～50岁村民进行HIV感染率调查，并进行定群研究。结果 1997年调查了963人，发现HIV抗体阳性者17例，HIV感染率为1.8%。其中有偿献血员88人，15例为HIV抗体阳性，HIV感染率为17.0%, 显著高于非献血人群(0.2%)。1998年和2000年进行了随访，其中HIV抗体阴性人群668人，共随访1 742人年，仅1例出现HIV抗体阳转，发病率为每百人年0.06。阳性人群和阴性人群均有一半人群有肌注史。13例HIV感染者配偶随访尚未发现HIV抗体阳转者。HIV感染者CD4细胞计数逐年下降，对5例HIV感染者进行了基因序列分析，全部为HIV-1B′亚型毒株，基因离散率平均为2.4%。结论 中国局部地区有偿献血员中有较高的HIV感染率，献血(浆)是其感染HIV的主要危险因素，在3年观察期间该地区有偿献血员HIV感染率没有进一步发展，但仍应采取相应的措施预防其传播。 |
| 英文摘要: |
| Objective To observe the prevalence of HIV infection among paid blood donors and risk factors. Methods Selected the residents between 18 to 50 years old from two villages in one county of China in 1997. We observed the prevalence of HIV infection and keep following them to 2000. Results Nine hundred sixty-three residents were investigated and the prevalence of HIV was 1.8%(17/963).There were 88 paid blood donors among 963 interviewed subjects, the HIV prevalence was significantly higher (17.0% or 15/88) than those who didn't have the experiences of paid blood donations (0.2% or 2/875). Only one person out of 668 who were followed from 1997 to 2000 has converted to sero-positive, the incidence of HIV infection is 0.06 per 100 person-years. Nearly half of sero-negative and sero-positive people have the experiences of muscle injection. Among those with HIV-positive spouse, we found no one converted to sero-positive. The CD4 count of those sero-positive people declined every year. HIV subtype and C2-V3 region sequence analysis were made for five HIV-positive people in 1998, the result indicated that all of them were infected with HIV-1 subtype B′ and the genetic divergence rate was 2.4%. Conclusion There was a high prevalence of HIV among paid blood donors in some regions, and paid blood (plasma) donations were the main risk factor for HIV infection. Although no evidence suggests that during the follow-up period the epidemic of HIV infection has spread locally, it still shall take measurements to prevent further transmission of HIV through paid blood donors. |
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