| 张慧颖,王滨有,赵雪妮,孙俭宏,梁子君,张冬梅,杨泽,孙逸平,沈晶晶.哈尔滨市儿童Ⅰ型糖尿病与HLA-DRB1等位基因的关联研究[J].中华流行病学杂志,2000,21(4):267-269 |
| 哈尔滨市儿童Ⅰ型糖尿病与HLA-DRB1等位基因的关联研究 |
| The susceptible alleles on HLA-DRB1 of type Ⅰ diabetes in children in Harbin |
| 收稿日期:1999-10-21 出版日期:2014-09-16 |
| DOI： |
| 中文关键词: 糖尿病,儿童Ⅰ型(IDDM) 人类白细胞抗原DR等位基因 IDDM易感/保护基因 |
| 英文关键词: Type Ⅰ diabetes mellitus (IDDM) HLA-DR IDDM susceptibility / protection genes |
| 基金项目: |
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| 中文摘要: |
| 目的 哈尔滨市儿童Ⅰ型糖尿病与人类白细胞抗原DR位点(HLA-DRB1)等位基因的关联关系。方法 选取47例0～14岁发病的患者和94名非Ⅰ型糖尿病健康儿童对照，运用PCR-SSP技术测定HLA-DRB1等位基因型别。结果 在DR位点上，病例组的DRB1.0301频率和DR3/4杂合子频率显著高于非Ⅰ型糖尿病对照组，而DR2的频率显著低于对照组；DR4亚型中的DRB1.0405频率为病例组高于对照组，RB1.0406频率低于对照组；DRB1.0901频率在两组之间差异无显著性。结论 DR位点的DRB1.0301等位基因为哈尔滨市儿童Ⅰ型糖尿病的强易感基因，而DR2为保护性基因。DR3/4杂合子为易感性杂合子。证实了DR4亚型具有双重作用。未证实DRB1.0901有强易感性，因此，其在中国人Ⅰ型糖尿病患者的易感性作用还有待于进一步探索。 |
| 英文摘要: |
| Objective To evaluate association between type Ⅰ diabetes in children and HLA-DRB1 alleles in Harbin. Methods Case-control method was employed, and the PCR-SSP technique was used to identify HLA-DRB1 alleles. Results The frequencies of DRB1*0301 and DR3/4 heterozygosity were significantly higher but the frequency of DR2 was significantly lower in cases than that in controls. In DR4 subtypes, the frequency of DRB1*0405 was higher and the frequency of DRB1*0406 was lower in cases than that in the controls. The difference between cases and controls in DRB1*0901 was not significant. Conclusion DRB1*0301 allele and DR3/4 heterozygosity were the important susceptibility and heterozygosity genes while DR2 was the most important protective gene in Harbin. The DR4 possessed double-tendency. DRB1*0405 confered susceptibility and DRB1*0406 confered little protection. The susceptibility conferred by DRB1*0901 was not certain in type Ⅰ diabetes in childhood in China. This study provided useful genetic data on the study of etiology of type Ⅰ diabetes mellitus. |
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