文章摘要
何利华,尹焱,尤元海,闫笑梅,张建中.波利特、达克普隆和Nexium对幽门螺杆菌的体外抑菌效果比较[J].中华流行病学杂志,2003,24(6):447-448
波利特、达克普隆和Nexium对幽门螺杆菌的体外抑菌效果比较
In-vitro activity of rabeprazole lansoprazole and esomeprazole against Helicobacter pylori
投稿时间:2003-03-24  修订日期:2012-06-29
DOI:
中文关键词: 幽门螺杆菌;质子泵抑制剂
英文关键词: Helicobacter pylori;Proton pump inhibitors
基金项目:
作者单位
何利华 中国疾病预防控制中心传染病预防控制所传染病诊断室, 北京 102206 
尹焱 中国疾病预防控制中心传染病预防控制所传染病诊断室, 北京 102206 
尤元海 中国疾病预防控制中心传染病预防控制所传染病诊断室, 北京 102206 
闫笑梅 中国疾病预防控制中心传染病预防控制所传染病诊断室, 北京 102206 
张建中 中国疾病预防控制中心传染病预防控制所传染病诊断室, 北京 102206 
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中文摘要:
      目的观察、比较质子泵抑制剂(PPI)波利特(雷贝拉唑肠溶衣片)、达克普隆(兰索拉唑胶囊)和Nexium对幽门螺杆菌(Hp)的抑制作用,初步解释近期临床流行病学资料所显示的不同PPI用于Hp根除治疗所表现的明显效果差异现象。方法使用Hp国际标准株NCTC11637、NCTC11639和国内分离菌株CAPMN62,应用平板掺入法测定三种PPI对Hp的体外抑菌作用。结果波利特在体外对Hp具有明显的抑制作用(MIC99为2.25mg/L),其次为达克普隆(MIC99为42.5mg/L),而Nexium抑菌作用不明显(MIC99为360mg/L)。结论不同PPI对Hp的直接抑菌作用存在明显差异,其作用除本身化学结构的差异因素外,制剂中的其他复合成分的影响也不容忽视;亟待对体外抑菌效果与用于Hp感染治疗效果的相关性进行分析,以便更好地指导临床用药和相关幽门螺杆菌病的防治。
英文摘要:
      Objective To investigate the antimic;robial activity of Pariet, Tekpron,Nexium,respectively,against Helicobocter pylori (H. pylori) in vitro.Methods Antimicrobial effects of these medicines were evaluated through detertion of MICs for 3H. pylori strains isolated from different countries.Results The MIC99 contents were 2.25 mg/L,42.5mg/L and 360mg/L, respectively, for the three medicines. The strains under testing exhlblted the same susceptibility to each medicine. Nexium did not inhibit the bacteria under the concentration of 3. 6- 36 mg/L with more and bigger H. pylori colonies seen when compared with controls. Conclusions The growth inhibitory activity appeared to be different among the three.PPI medicines under investigation,with Rabeprazole the most potential agent of the three. Data suggested that the action of growth inhibition in testing on the characteristic of the given PPI as well as the supplements of the medicine.
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